An Abelson virus-transformed murine pre-B cell line class-switched from μ to γ3 or γ2b at the pre-b stage during culture. A class-swtich was mediated by the deletion mechanism of the intervening C(H) genes on the active chromosome. This study showed for the first time that class-switching at the pre-B cell stage was not always confined to γ2b production.
|Number of pages||6|
|Journal||Journal of Immunology|
|Publication status||Published - Jan 1 1986|
All Science Journal Classification (ASJC) codes
- Immunology and Allergy