Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells

Takashi Kimitsuki; Takashi Nakagawa; Kazutaka Hisashi; Shizuo Komune; Sohtaro Komiyama

doi:10.1016/0378-5955(93)90021-R

Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells

Takashi Kimitsuki, Takashi Nakagawa, Kazutaka Hisashi, Shizuo Komune, Sohtaro Komiyama

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Abstract

The effects of cisplatin (cis-dichlorodiammine platinum II, CDDP) on the mechano-electrical transduction (MET) current were investigated with a whole-cell patch-electrode voltage clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET channel in a dose-and voltage-dependent manner. At -50 mV, CDDP blocked the MET channel with a Hill coefficient of approximately 2 and a dissociation constant (K_D) of 1.5×10^-3 M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage-dependent component.

Original language	English
Pages (from-to)	64-68
Number of pages	5
Journal	Hearing Research
Volume	71
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-5955(93)90021-R
Publication status	Published - Dec 1993

All Science Journal Classification (ASJC) codes

Sensory Systems

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10.1016/0378-5955(93)90021-R

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title = "Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells",

abstract = "The effects of cisplatin (cis-dichlorodiammine platinum II, CDDP) on the mechano-electrical transduction (MET) current were investigated with a whole-cell patch-electrode voltage clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET channel in a dose-and voltage-dependent manner. At -50 mV, CDDP blocked the MET channel with a Hill coefficient of approximately 2 and a dissociation constant (KD) of 1.5×10-3 M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage-dependent component.",

author = "Takashi Kimitsuki and Takashi Nakagawa and Kazutaka Hisashi and Shizuo Komune and Sohtaro Komiyama",

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T1 - Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells

AU - Kimitsuki, Takashi

AU - Nakagawa, Takashi

AU - Hisashi, Kazutaka

AU - Komune, Shizuo

AU - Komiyama, Sohtaro

PY - 1993/12

Y1 - 1993/12

N2 - The effects of cisplatin (cis-dichlorodiammine platinum II, CDDP) on the mechano-electrical transduction (MET) current were investigated with a whole-cell patch-electrode voltage clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET channel in a dose-and voltage-dependent manner. At -50 mV, CDDP blocked the MET channel with a Hill coefficient of approximately 2 and a dissociation constant (KD) of 1.5×10-3 M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage-dependent component.

AB - The effects of cisplatin (cis-dichlorodiammine platinum II, CDDP) on the mechano-electrical transduction (MET) current were investigated with a whole-cell patch-electrode voltage clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET channel in a dose-and voltage-dependent manner. At -50 mV, CDDP blocked the MET channel with a Hill coefficient of approximately 2 and a dissociation constant (KD) of 1.5×10-3 M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage-dependent component.

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ER -

Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells

Abstract

All Science Journal Classification (ASJC) codes

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