Circumscribed mass lesions on mammography: Dynamic contrast-enhanced MR imaging to differentiate malignancy and benignancy

Takashi Okafuji, Hidetake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takeshi Kamitani, Shuji Sakai, Masamitsu Hatakenaka, Syoji Kuroki, Eriko Tokunaga, Hidetaka Yamamoto, Hiroshi Honda

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Purpose: We evaluated the magnetic resonance (MR) features of breast lesions showing circumscribed mass on mammography to understand the characteristics that differentiate malignancy and benignancy. Materials and Methods: Our institutional review board approved the study, and informed consent was waived. Using logistic regression analysis, we examined morphologic and kinetic MR imaging data of 90 breast lesions (43 malignant, 47 benign) that showed circumscribed mass on mammography. Results: Features identified as having high odds for malignancy included: rim enhancement (odds ratio, 70.894; 95% confidence interval (CI), 7.525-667.938); heterogeneous enhancement (odds ratio, 10.839; 95z CI, 1.032-113.856); and washout dynamic pattern (odds ratio, 46.262; 95z CI, 3.716-575.901). Combinations of washout dynamic pattern and either rim or heterogeneous enhancement reflected excessively high prediction probability for malignancy (>0.95), whereas combinations lacking washout dynamic pattern and with either homogeneous enhancement or dark internal septation revealed excessively low prediction probability for malignancy (<0.05). Conclusion: Breast cancers with circumscribed mass on mammography could be differentiated from benign masses using internal enhancement and the kinetic pattern of contrast-enhanced breast MR imaging.

Original languageEnglish
Pages (from-to)195-204
Number of pages10
JournalMagnetic Resonance in Medical Sciences
Issue number4
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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