Circadian rhythm of fever induced by interferon-α in mice

Shigehiro Ohdo, Satoru Koyanagi, Eiji Yukawa, Shun Higuchi

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17 Citations (Scopus)


The influence of dosing time on the fever induced by interferon-α: (IFN-α) was investigated in ICR male mice under light-dark cycle. There was a significant circadian rhythm in rectal temperature, as an index of fever, at 1 hr after IFN-α (10 MIU/kg, i.v.) injection. The rhythmic pattern resembled overall the rhythm occuring in the nondrugged state. IFN-α increased rectal temperature during the light phase, but not during the dark phase. The fever induced by IFN-α was blocked by indomethacin (10 mg/kg, i.p.) pretreatment. There was no significant difference of plasma IFN-α concentrations at 0.167, 0.5 and 1 hr after IFN-α injection. Therefore the dosing time dependent difference of fever induced by IFN-α may be caused via that of PGE2 level elevated by IFN-α. The choice of the most appropriate time of day for drug administration may help to achieve rational chronotherapeutics of IFN- α.

Original languageEnglish
Pages (from-to)PL95-PL100
JournalLife Sciences
Issue number8
Publication statusPublished - Jul 18 1997

All Science Journal Classification (ASJC) codes

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry,Genetics and Molecular Biology


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