Chronobiological analysis of a new clock mutant, toki, in drosophila melanogaster

Akira Matsumoto, Takehiro Motoshige, Takehide Murata, Kenji Tomioka, Teiichi Tanimura, Yoshihiko Chiba

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38 Citations (Scopus)


We have isolated a new semidominant clock mutant Toki on the second chromosome in Drosophila melanogaster. This mutant differs from the wild-type Canton-S in several properties as follows. Larger values are obtained in the phase angle difference (ψ the time from lights-off in a 24-hr light-dark cycle to an activity offset), the ratio of activity time to rest time (αrho; and the activity level. The free-running period (τ is 25.3 hr, one hour longer than in the wild-type. In the phase response curve (PRC), the ratio between the delay and the advance portion is larger and the cross-over point occurs later, although there is no difference in amplitude of the mutant's PRC (Type I). The rhythm is more sensitive to the light intensity, becoming obscure in darker condition. Toki interacts with other clock mutations, perS, perL and And, in such a way that τ s associated with these three X-linked mutations are lengthened and ψ values become smaller.

Original languageEnglish
Pages (from-to)141-155
Number of pages15
JournalJournal of Neurogenetics
Issue number3
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cellular and Molecular Neuroscience


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