[Chrono-drug delivery system based on the circadian rhythm of transferrin receptor].

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1 Citation (Scopus)


Transferrin receptor 1(TfR1) is a key cell surface molecule that regulates the uptake of iron-bound transferrin. TfR1 expression is higher in tumor cells than in normal cells. Thus, intracellular targeting using iron-saturated Tf as a ligand for TfR-mediated endocytosis has attracted attention. TfR1 in colon cancer-bearing mice exhibits a 24-hour rhythm in mRNA and protein levels. The clock-controlled gene c-MYC rhythmically activate the transcription of the TfR1 gene. In addition, the cyclical accumulation of TfR1 causes dosing time-dependent changes in the intratumoral delivery of drug by receptor-mediated endocytosis. Identification of the circadian properties of molecules that are targeted by ligand-directed DDS may aid the choice of the most appropriate time of day for their administration.

Original languageEnglish
Pages (from-to)2200-2205
Number of pages6
JournalUnknown Journal
Issue number12
Publication statusPublished - Dec 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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