Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Hiroaki Ogata; Isamu Okamoto; Goichi Yoshimoto; Teppei Obara; Kayo Ijichi; Eiji Iwama; Taishi Harada; Koichi Akashi; Yoichi Nakanishi

doi:10.1016/j.resinv.2016.12.002

Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Hiroaki Ogata, Isamu Okamoto, Goichi Yoshimoto, Teppei Obara, Kayo Ijichi, Eiji Iwama, Taishi Harada, Koichi Akashi, Yoichi Nakanishi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 59-year-old woman with epidermal growth factor receptor gene (EGFR) mutation–positive advanced lung adenocarcinoma was treated with afatinib after a diagnosis of chronic myelomonocytic leukemia (CMML). Twenty-one weeks later, she developed agranulocytosis, and CMML subsequently progressed to blast crisis. After complete remission of CMML, gefitinib was initiated; however, agranulocytosis recurred. This is the first reported case of both EGFR mutation–positive advanced non-small cell lung cancer with CMML, and of CMML blast crisis. Physicians should be aware of such risks and monitor EGFR-TKI–treated patients with myeloid neoplasms accordingly.

Original language	English
Pages (from-to)	181-183
Number of pages	3
Journal	Respiratory Investigation
Volume	55
Issue number	2
DOIs	https://doi.org/10.1016/j.resinv.2016.12.002
Publication status	Published - Mar 1 2017

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.resinv.2016.12.002

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title = "Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors",

abstract = "A 59-year-old woman with epidermal growth factor receptor gene (EGFR) mutation–positive advanced lung adenocarcinoma was treated with afatinib after a diagnosis of chronic myelomonocytic leukemia (CMML). Twenty-one weeks later, she developed agranulocytosis, and CMML subsequently progressed to blast crisis. After complete remission of CMML, gefitinib was initiated; however, agranulocytosis recurred. This is the first reported case of both EGFR mutation–positive advanced non-small cell lung cancer with CMML, and of CMML blast crisis. Physicians should be aware of such risks and monitor EGFR-TKI–treated patients with myeloid neoplasms accordingly.",

author = "Hiroaki Ogata and Isamu Okamoto and Goichi Yoshimoto and Teppei Obara and Kayo Ijichi and Eiji Iwama and Taishi Harada and Koichi Akashi and Yoichi Nakanishi",

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T1 - Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

AU - Ogata, Hiroaki

AU - Okamoto, Isamu

AU - Yoshimoto, Goichi

AU - Obara, Teppei

AU - Ijichi, Kayo

AU - Iwama, Eiji

AU - Harada, Taishi

AU - Akashi, Koichi

AU - Nakanishi, Yoichi

PY - 2017/3/1

Y1 - 2017/3/1

N2 - A 59-year-old woman with epidermal growth factor receptor gene (EGFR) mutation–positive advanced lung adenocarcinoma was treated with afatinib after a diagnosis of chronic myelomonocytic leukemia (CMML). Twenty-one weeks later, she developed agranulocytosis, and CMML subsequently progressed to blast crisis. After complete remission of CMML, gefitinib was initiated; however, agranulocytosis recurred. This is the first reported case of both EGFR mutation–positive advanced non-small cell lung cancer with CMML, and of CMML blast crisis. Physicians should be aware of such risks and monitor EGFR-TKI–treated patients with myeloid neoplasms accordingly.

AB - A 59-year-old woman with epidermal growth factor receptor gene (EGFR) mutation–positive advanced lung adenocarcinoma was treated with afatinib after a diagnosis of chronic myelomonocytic leukemia (CMML). Twenty-one weeks later, she developed agranulocytosis, and CMML subsequently progressed to blast crisis. After complete remission of CMML, gefitinib was initiated; however, agranulocytosis recurred. This is the first reported case of both EGFR mutation–positive advanced non-small cell lung cancer with CMML, and of CMML blast crisis. Physicians should be aware of such risks and monitor EGFR-TKI–treated patients with myeloid neoplasms accordingly.

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Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Abstract

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