Chronic hypertrophic cranial pachymeningitis associated with HTLV-I infection

Y. Kawano, J. Kira

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50 Citations (Scopus)


Two patients presenting with recurrent multiple cranial neuropathy showed diffuse thickening and gadolinium enhancement of the dura mater on brain MRI. Both had anti-HTLV-I antibodies in serum. A quantitative polymerase chain reaction study ofthe peripheral blood disclosed that the HTLV-I proviral DNA loads increased considerably in one case and moderately in the other. Both showed a spontaneous proliferation of peripheral blood lymphocytes as well as an increase in helper/inducer T cells. Neither had any other underlying infections or autoimmune diseases. Thus it is possible that hypertrophic pachymeningitis developed as a result of multiorgan involvement of HTLV-I infection in these patients.

Original languageEnglish
Pages (from-to)435-437
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number4
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


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