TY - JOUR
T1 - Chromatin remodeling in neural stem cell differentiation
AU - Juliandi, Berry
AU - Abematsu, Masahiko
AU - Nakashima, Kinichi
N1 - Funding Information:
We apologize to colleagues whose work we may not have been able to include in this review due to space constraints. We thank our laboratory members for useful discussions on this topic, and Ian Smith for critical reading of the manuscript. We have been supported by a Grant-in-Aid for Scientific Research on Priority Areas-Molecular Brain Research and the NAIST Global COE Program (Frontier Biosciences: Strategies for Survival and Adaptation in a Changing Global Environment) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2010/8
Y1 - 2010/8
N2 - Chromatin remodeling is a dynamic alteration of chromatin structure that regulates several important biological processes. It is brought about by enzymatic activities that catalyze covalent modifications of histone tail or movement of nucleosomes along the DNA, and these activities often require multisubunit protein complexes for its proper functions. In concert with DNA methylation and noncoding RNA-mediated processes, histone modification such as acetylation and methylation regulates gene expression epigenetically, without affecting DNA sequence. Recent advances have revealed that this intrinsic regulation, together with protein complexes such as RE1 silencer of transcription/neuron-restrictive silencer factor (REST/NRSF) and switch/sucrose nonfermentable (SWI/SNF), play critical roles in neural stem cell fate determination.
AB - Chromatin remodeling is a dynamic alteration of chromatin structure that regulates several important biological processes. It is brought about by enzymatic activities that catalyze covalent modifications of histone tail or movement of nucleosomes along the DNA, and these activities often require multisubunit protein complexes for its proper functions. In concert with DNA methylation and noncoding RNA-mediated processes, histone modification such as acetylation and methylation regulates gene expression epigenetically, without affecting DNA sequence. Recent advances have revealed that this intrinsic regulation, together with protein complexes such as RE1 silencer of transcription/neuron-restrictive silencer factor (REST/NRSF) and switch/sucrose nonfermentable (SWI/SNF), play critical roles in neural stem cell fate determination.
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U2 - 10.1016/j.conb.2010.04.001
DO - 10.1016/j.conb.2010.04.001
M3 - Review article
C2 - 20434901
AN - SCOPUS:77956405805
SN - 0959-4388
VL - 20
SP - 408
EP - 415
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 4
ER -