Cholinergic neurotransmission is not involved in sedation induced by L-proline in neonatal chicks

K. Hamasu, K. Shigemi, Y. Tsuneyoshi, H. Sato, D. M. Denbow, M. Furuse

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The aim of the present study was to determine whether the sedative effects of L-proline are associated with the modulation of cholinergic neurotransmission. We investigated the effect of co-injection of L-proline with scopolamine, a Muscarinic Acetylcholine Receptor (M-AChR) antagonist, on behavior of neonatal chicks under isolation-induced stress. Intracerebroventricular (i.c.v.) injection of L-proline reduced spontaneous activity and the number of distress vocalizations, while co-injected scopolamine did not attenuate this effect implying that the M-AChR was not involved in the sedative effects induced by L-proline. In addition, the effect of L-proline on acetylcholineesterase activity in the telencephalon and diencephalon of chicks was investigated. No significant changes m acetylcholineesterase activity were observed in either the telencephalon or diencephalon. These results indicate that the sedative effects induced by L-proline are not mediated by the cholinergic system.

Original languageEnglish
Pages (from-to)1207-1211
Number of pages5
JournalJournal of Animal and Veterinary Advances
Issue number6
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Agronomy and Crop Science
  • General Veterinary


Dive into the research topics of 'Cholinergic neurotransmission is not involved in sedation induced by L-proline in neonatal chicks'. Together they form a unique fingerprint.

Cite this