Chimeric Adeno-Associated Virus-Mediated Cardiovascular Reprogramming for Ischemic Heart Disease

So Young Yoo; Su Nam Jeong; Jeong In Kang; Seung Wuk Lee

doi:10.1021/acsomega.8b00904

Chimeric Adeno-Associated Virus-Mediated Cardiovascular Reprogramming for Ischemic Heart Disease

So Young Yoo, Su Nam Jeong, Jeong In Kang, Seung Wuk Lee

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Here, we demonstrated chimeric adeno-associated virus (chimeric AAV), AAV-DJ-mediated cardiovascular reprogramming strategy to generate new cardiomyocytes and limit collagen deposition in cardiac fibroblasts by inducing synergism of chimeric AAV-expressing Gata4, Mef2c, Tbx5 (AAV-GMT)-mediated heart reprogramming and chimeric AAV-expressing thymosin β4 (AAV-Tβ4)-mediated heart regeneration. AAV-GMT promoted a gradual increase in expression of cardiac-specific genes, including Actc1, Gja1, Myh6, Ryr2, and cTnT, with a gradual decrease in expression of a fibrosis-specific gene, procollagen type I and here AAV-Tβ4 help to induce GMT expression, providing a chimeric AAV-mediated therapeutic cell reprogramming strategy for ischemic heart diseases.

Original language	English
Pages (from-to)	5918-5925
Number of pages	8
Journal	ACS Omega
Volume	3
Issue number	5
DOIs	https://doi.org/10.1021/acsomega.8b00904
Publication status	Published - May 31 2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

Access to Document

10.1021/acsomega.8b00904

Cite this

@article{0d0022ae5d0049cd840b84acd259cd6e,

title = "Chimeric Adeno-Associated Virus-Mediated Cardiovascular Reprogramming for Ischemic Heart Disease",

abstract = "Here, we demonstrated chimeric adeno-associated virus (chimeric AAV), AAV-DJ-mediated cardiovascular reprogramming strategy to generate new cardiomyocytes and limit collagen deposition in cardiac fibroblasts by inducing synergism of chimeric AAV-expressing Gata4, Mef2c, Tbx5 (AAV-GMT)-mediated heart reprogramming and chimeric AAV-expressing thymosin β4 (AAV-Tβ4)-mediated heart regeneration. AAV-GMT promoted a gradual increase in expression of cardiac-specific genes, including Actc1, Gja1, Myh6, Ryr2, and cTnT, with a gradual decrease in expression of a fibrosis-specific gene, procollagen type I and here AAV-Tβ4 help to induce GMT expression, providing a chimeric AAV-mediated therapeutic cell reprogramming strategy for ischemic heart diseases.",

author = "Yoo, {So Young} and Jeong, {Su Nam} and Kang, {Jeong In} and Lee, {Seung Wuk}",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = may,

day = "31",

doi = "10.1021/acsomega.8b00904",

language = "English",

volume = "3",

pages = "5918--5925",

journal = "ACS Omega",

issn = "2470-1343",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Chimeric Adeno-Associated Virus-Mediated Cardiovascular Reprogramming for Ischemic Heart Disease

AU - Yoo, So Young

AU - Jeong, Su Nam

AU - Kang, Jeong In

AU - Lee, Seung Wuk

PY - 2018/5/31

Y1 - 2018/5/31

N2 - Here, we demonstrated chimeric adeno-associated virus (chimeric AAV), AAV-DJ-mediated cardiovascular reprogramming strategy to generate new cardiomyocytes and limit collagen deposition in cardiac fibroblasts by inducing synergism of chimeric AAV-expressing Gata4, Mef2c, Tbx5 (AAV-GMT)-mediated heart reprogramming and chimeric AAV-expressing thymosin β4 (AAV-Tβ4)-mediated heart regeneration. AAV-GMT promoted a gradual increase in expression of cardiac-specific genes, including Actc1, Gja1, Myh6, Ryr2, and cTnT, with a gradual decrease in expression of a fibrosis-specific gene, procollagen type I and here AAV-Tβ4 help to induce GMT expression, providing a chimeric AAV-mediated therapeutic cell reprogramming strategy for ischemic heart diseases.

AB - Here, we demonstrated chimeric adeno-associated virus (chimeric AAV), AAV-DJ-mediated cardiovascular reprogramming strategy to generate new cardiomyocytes and limit collagen deposition in cardiac fibroblasts by inducing synergism of chimeric AAV-expressing Gata4, Mef2c, Tbx5 (AAV-GMT)-mediated heart reprogramming and chimeric AAV-expressing thymosin β4 (AAV-Tβ4)-mediated heart regeneration. AAV-GMT promoted a gradual increase in expression of cardiac-specific genes, including Actc1, Gja1, Myh6, Ryr2, and cTnT, with a gradual decrease in expression of a fibrosis-specific gene, procollagen type I and here AAV-Tβ4 help to induce GMT expression, providing a chimeric AAV-mediated therapeutic cell reprogramming strategy for ischemic heart diseases.

UR - http://www.scopus.com/inward/record.url?scp=85047966915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047966915&partnerID=8YFLogxK

U2 - 10.1021/acsomega.8b00904

DO - 10.1021/acsomega.8b00904

M3 - Article

AN - SCOPUS:85047966915

SN - 2470-1343

VL - 3

SP - 5918

EP - 5925

JO - ACS Omega

JF - ACS Omega

IS - 5

ER -

Chimeric Adeno-Associated Virus-Mediated Cardiovascular Reprogramming for Ischemic Heart Disease

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this