Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)

Nozomu Kawashima, Akira Shimada, Takeshi Taketani, Yasuhide Hayashi, Nao Yoshida, Kimikazu Matsumoto, Yoshiyuki Takahashi, Seiji Kojima, Koji Kato

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Acute myeloid leukemia with abnormal bone marrow eosinophilia (AML-M4Eo) is often reported in core binding factor (CBF) leukemia, with translocations such as inv(16)(p13q22), t(16;16)(p13;q22) or t(8;21)(q22;q22); however, it is rarely reported with t(16;21)(q24;q22), which produces the RUNX1-CBFA2T3 (AML1-MTG16) chimera. The similarity between this chimera and RUNX1-RUNXT1 (AML1-MTG8) by t(8;21)(q22;q22) remains controversial. Adult leukemia with t(16;21)(q24;q22) was primarily therapy related, and shows poor prognosis; however, pediatric AML with this translocation was quite rare and tended to be de novo AML. We present here a 4-year-old boy with de novo AML-M4Eo and t(16;21) (q24;q22). He received chemotherapy and survived for more than 70 months without transplantation. We speculated that pediatric AML with t(16;21)(q24;q22) showed favorable prognosis, as with t(8;21)(q22;q22).

Original languageEnglish
Pages (from-to)577-580
Number of pages4
JournalInternational journal of hematology
Issue number5
Publication statusPublished - May 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology


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