TY - JOUR
T1 - Chicken ghrelin and growth hormone-releasing peptide-2 inhibit food intake of neonatal chicks
AU - Saito, Ei suke
AU - Kaiya, Hiroyuki
AU - Takagi, Tomo
AU - Yamasaki, Izumi
AU - Denbow, D. Michael
AU - Kangawa, Kenji
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan. We are grateful to Yasuo Kitajima, Masaru Matsumoto, Yoshiharu Minamitake at the Suntory Institute for Medicinal Research and Development, Gunma, Japan for synthesizing chicken and bullfrog ghrelin, and to the Kaken Pharmaceutical (Tokyo, Japan) for gifting GHRP-2 (KP-102).
PY - 2002/10/18
Y1 - 2002/10/18
N2 - Ghrelin is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Ghrelin stimulates feeding in rats, however, intracerebroventricular (i.c.v.) injection of rat ghrelin inhibits feeding of neonatal chicks. In the present study, the effect of i.c.v. injection of different ghrelins including chicken and bullfrog ghrelin, and synthetic GH-releasing peptide (GHRP) on feeding of neonatal chicks was investigated. Chicken ghrelin strongly suppressed feeding. To compare the inhibitory effect, chicken and rat ghrelin were examined. The suppressive effect of feeding by chicken and rat ghrelin was almost identical. Bullfrog ghrelin contains a change in the acylated amino acid from Ser to Thr, strongly suppressed feeding. The i.c.v. injection of GHRP-2 (KP-102), a synthetic GHS, also inhibited feeding. These results indicate that the chicken GHS receptor is affected by several forms of GHS, and that food intake of neonatal chicks is inhibited by GHS receptor agonists.
AB - Ghrelin is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Ghrelin stimulates feeding in rats, however, intracerebroventricular (i.c.v.) injection of rat ghrelin inhibits feeding of neonatal chicks. In the present study, the effect of i.c.v. injection of different ghrelins including chicken and bullfrog ghrelin, and synthetic GH-releasing peptide (GHRP) on feeding of neonatal chicks was investigated. Chicken ghrelin strongly suppressed feeding. To compare the inhibitory effect, chicken and rat ghrelin were examined. The suppressive effect of feeding by chicken and rat ghrelin was almost identical. Bullfrog ghrelin contains a change in the acylated amino acid from Ser to Thr, strongly suppressed feeding. The i.c.v. injection of GHRP-2 (KP-102), a synthetic GHS, also inhibited feeding. These results indicate that the chicken GHS receptor is affected by several forms of GHS, and that food intake of neonatal chicks is inhibited by GHS receptor agonists.
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U2 - 10.1016/S0014-2999(02)02393-2
DO - 10.1016/S0014-2999(02)02393-2
M3 - Article
C2 - 12393062
AN - SCOPUS:0037130990
SN - 0014-2999
VL - 453
SP - 75
EP - 79
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -