TY - JOUR
T1 - Chemotherapy for enterohemorrhagic Escherichia coli O157:H infection in a mouse model
AU - Yoshimura, Kazuaki
AU - Fujii, Jun
AU - Taniguchi, Hatsumi
AU - Yoshida, Shin ichi
N1 - Funding Information:
This study was supported by a grant for emerging and re-emerging infectious disease from the Ministry of Health and Welfare, Japan.
PY - 1999/11
Y1 - 1999/11
N2 - The aim of this study is to evaluate the therapeutic effect of the antimicrobial agents, fosfomycin (FOM), minocycline (MINO), kanamycin (KM) and norfloxacin (NFLX) in the enterohemorrhagic Escherichia coli (EHEC) infected mouse model which we established previously (Infect. Immun. 62 (1994) 3447-3453). Each of the antimicrobial agents, 1/16 LD50, was given to the mice per os (p.o.) or intraperitoneally (i.p.) for 3 days after bacterial inoculation and then we observed their mortality rate for 2 weeks. The mortality rates of mice administered with MINO (p.o./i.p.), KM (p.o.), NFLX (p.o./i.p.) were significantly lower than those of the control group. Both the bacterial number and VT2c level in the feces of the FOM group were lower than those of the NFLX group on day 1, but reversed on day 3. In an in vitro experiment, each of the four drugs in combination with mitomycin C (MMC) caused a more significant decrease in the bacterial number than sole MMC, and they consequently indicated the suppressive effect on the release of VT2c. Copyright (C) 1999 Federation of European Microbiological Societies.
AB - The aim of this study is to evaluate the therapeutic effect of the antimicrobial agents, fosfomycin (FOM), minocycline (MINO), kanamycin (KM) and norfloxacin (NFLX) in the enterohemorrhagic Escherichia coli (EHEC) infected mouse model which we established previously (Infect. Immun. 62 (1994) 3447-3453). Each of the antimicrobial agents, 1/16 LD50, was given to the mice per os (p.o.) or intraperitoneally (i.p.) for 3 days after bacterial inoculation and then we observed their mortality rate for 2 weeks. The mortality rates of mice administered with MINO (p.o./i.p.), KM (p.o.), NFLX (p.o./i.p.) were significantly lower than those of the control group. Both the bacterial number and VT2c level in the feces of the FOM group were lower than those of the NFLX group on day 1, but reversed on day 3. In an in vitro experiment, each of the four drugs in combination with mitomycin C (MMC) caused a more significant decrease in the bacterial number than sole MMC, and they consequently indicated the suppressive effect on the release of VT2c. Copyright (C) 1999 Federation of European Microbiological Societies.
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U2 - 10.1016/S0928-8244(99)00119-4
DO - 10.1016/S0928-8244(99)00119-4
M3 - Article
C2 - 10536295
AN - SCOPUS:0032884717
SN - 0928-8244
VL - 26
SP - 101
EP - 108
JO - FEMS Immunology and Medical Microbiology
JF - FEMS Immunology and Medical Microbiology
IS - 2
ER -
