TY - JOUR
T1 - Chemosensitivity test for carcinoma of digestive organs
AU - Maehara, Yoshihiko
AU - Kohnoe, Shunji
AU - Sugimachi, Keizo
PY - 1990
Y1 - 1990
N2 - For the chemosensitivity for carcinoma of digestive organs, gastric, colorectal, and hepatic cancer tissues were examined using in vitro succinate dehydrogenase inhibition (SDI) test and in vivo subrenal capsule (SRC) assay. The chemosensitivity varied in the tissue. The origin of an organ tumor, histological differentiation, and difference of primary or metastatic lesions are critical for determining chemosensitivity. Biochemical analysis shows that antitumor drugs have an increased susceptibility in tissues with high activity of pyrimidine nucleotide synthesis.
AB - For the chemosensitivity for carcinoma of digestive organs, gastric, colorectal, and hepatic cancer tissues were examined using in vitro succinate dehydrogenase inhibition (SDI) test and in vivo subrenal capsule (SRC) assay. The chemosensitivity varied in the tissue. The origin of an organ tumor, histological differentiation, and difference of primary or metastatic lesions are critical for determining chemosensitivity. Biochemical analysis shows that antitumor drugs have an increased susceptibility in tissues with high activity of pyrimidine nucleotide synthesis.
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U2 - 10.1002/ssu.2980060109
DO - 10.1002/ssu.2980060109
M3 - Article
C2 - 2154026
AN - SCOPUS:0025214552
SN - 8756-0437
VL - 6
SP - 42
EP - 47
JO - Seminars in Surgical Oncology
JF - Seminars in Surgical Oncology
IS - 1
ER -
