TY - JOUR
T1 - Characterization of natural killer cells in tamarins
T2 - A technical basis for studies of innate immunity
AU - Yoshida, Tomoyuki
AU - Saito, Akatsuki
AU - Iwasaki, Yuki
AU - Iijima, Sayuki
AU - Kurosawa, Terue
AU - Katakai, Yuko
AU - Yasutomi, Yasuhiro
AU - Reimann, Keith A.
AU - Hayakawa, Toshiyuki
AU - Akari, Hirofumi
PY - 2010
Y1 - 2010
N2 - Natural killer (NK) cells are capable of regulating viral infection without major histocompatibility complex restriction. Hepatitis C is caused by chronic infection with hepatitis C virus (HCV), and impaired activity of NK cells may contribute to the control of the disease progression, although the involvement of NK cells in vivo remains to be proven. GB virus B (GBV-B), which is genetically most closely related to HCV, induces acute and chronic hepatitis upon experimental infection of tamarins. This non-human primate model seems likely to be useful for unveiling the roles of NK cells in vivo. Here we characterized the biological phenotypes of NK cells in tamarins and found that depletion of the CD16+ subset in vivo by administration of a monoclonal antibody significantly reduced the number and activity of NK cells.
AB - Natural killer (NK) cells are capable of regulating viral infection without major histocompatibility complex restriction. Hepatitis C is caused by chronic infection with hepatitis C virus (HCV), and impaired activity of NK cells may contribute to the control of the disease progression, although the involvement of NK cells in vivo remains to be proven. GB virus B (GBV-B), which is genetically most closely related to HCV, induces acute and chronic hepatitis upon experimental infection of tamarins. This non-human primate model seems likely to be useful for unveiling the roles of NK cells in vivo. Here we characterized the biological phenotypes of NK cells in tamarins and found that depletion of the CD16+ subset in vivo by administration of a monoclonal antibody significantly reduced the number and activity of NK cells.
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U2 - 10.3389/fmicb.2010.00128
DO - 10.3389/fmicb.2010.00128
M3 - Article
C2 - 21713119
AN - SCOPUS:84856404315
SN - 1664-302X
VL - 1
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
IS - DEC
ER -
