TY - JOUR
T1 - Characterization of macroporous carbonate-substituted hydroxyapatite bodies prepared in different phosphate solutions
AU - Lee, Yoong
AU - Hahm, Yeong Min
AU - Matsuya, Shigeki
AU - Nakagawa, Masaharu
AU - Ishikawa, Kunio
N1 - Funding Information:
Acknowledgements This study was supported in part by a Grant-in-aid for Scientific Research from the Ministry of Education, Sports, Culture, Science, and Technology, Japan
PY - 2007/9
Y1 - 2007/9
N2 - Bone mineral of human is different in composition from the stoichiometric hydroxyapatite (Ca10(PO4)6(OH)2) in that it contains additional ions, of which CO 3 2- is the most abundant species. Carbonate-substituted hydroxyapatite (CHA) bodies were prepared by the hydrothermal treatment of highly porous calcium carbonate (CaCO3) body at 120 °C in 1 M M2HPO4 and M3PO4 solutions (M = NH4 or K). It was found that CaCO3 body was almost transformed into CHA body after hydrothermal treatment for 24 h irrespective of type of phosphate solution. However, a small amount of CaCO3 still remained after the treatment in K3PO4 for 48 h. Crystal shape of CHA bodies prepared in those solutions except for K2HPO4 was flake-like, which was different from that (stick-like) of original CaCO3 body used for the preparation of CHA body. CHA prepared in the K2HPO4 showed globule-like crystal. Average pore size and hole size of the CHA bodies were 150, 70 μm and their porosities were about 89% irrespective of the solution. Carbonate content was slightly higher in the CHA bodies obtained from potassium phosphate solutions than in those obtained from ammonium phosphate solutions. Mostly B-type CHA was obtained after the hydrothermal treatment in the potassium phosphate solutions. On the other hand, mixed A- and B-type CHA (ca. 1-2 in molar ratio) was obtained in the ammonium phosphate solutions. The content of CO 3 2- in the CHA body depended on the type of phosphate solution and was slightly larger in the potassium phosphate solutions.
AB - Bone mineral of human is different in composition from the stoichiometric hydroxyapatite (Ca10(PO4)6(OH)2) in that it contains additional ions, of which CO 3 2- is the most abundant species. Carbonate-substituted hydroxyapatite (CHA) bodies were prepared by the hydrothermal treatment of highly porous calcium carbonate (CaCO3) body at 120 °C in 1 M M2HPO4 and M3PO4 solutions (M = NH4 or K). It was found that CaCO3 body was almost transformed into CHA body after hydrothermal treatment for 24 h irrespective of type of phosphate solution. However, a small amount of CaCO3 still remained after the treatment in K3PO4 for 48 h. Crystal shape of CHA bodies prepared in those solutions except for K2HPO4 was flake-like, which was different from that (stick-like) of original CaCO3 body used for the preparation of CHA body. CHA prepared in the K2HPO4 showed globule-like crystal. Average pore size and hole size of the CHA bodies were 150, 70 μm and their porosities were about 89% irrespective of the solution. Carbonate content was slightly higher in the CHA bodies obtained from potassium phosphate solutions than in those obtained from ammonium phosphate solutions. Mostly B-type CHA was obtained after the hydrothermal treatment in the potassium phosphate solutions. On the other hand, mixed A- and B-type CHA (ca. 1-2 in molar ratio) was obtained in the ammonium phosphate solutions. The content of CO 3 2- in the CHA body depended on the type of phosphate solution and was slightly larger in the potassium phosphate solutions.
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U2 - 10.1007/s10853-007-1629-3
DO - 10.1007/s10853-007-1629-3
M3 - Article
AN - SCOPUS:34547166504
SN - 0022-2461
VL - 42
SP - 7843
EP - 7849
JO - Journal of Materials Science
JF - Journal of Materials Science
IS - 18
ER -