Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children

Hiroyuki Sawatari, Anita Rahmawati, Nobuko Moriyama, Kanae Fujita, Tomoko Ohkusa, Tomoko Nao, Nobuko Hashiguchi, Mari Nishizaka, Shin ichi Ando, Akiko Chishaki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Compared with typically developing control children (CC), children with Down syndrome (DS) frequently exhibit sleep-disordered breathing (SDB) and unusual sleep postures (USPs). No studies have directly compared SDB-related signs and symptoms, SDB-related parameters, and USPs between children with DS and CC. This study aimed to evaluate the prevalences of SDB and USPs in children with DS and CC. Methods: We analyzed SDB-related parameters measured via overnight pulse oximetry and questionnaires administered to parents on SDB-related signs and symptoms, including sleeping postures. Estimated SDB was defined as a 3% oxygen desaturation index (ODI) ≥5 dips/h. Results: Fifty-one children with DS (4–5 years: N = 12, 6–10 years: N = 23, 11–15 years: N = 16) and sixty-three CC (4–5 years: N = 18, 6–10 years: N = 27, 11–15 years: N = 18) were included. The prevalence of estimated SDB and observed USPs was higher in children with DS than in CC (p < 0.0001). Among children aged 11–15 years old, but not those aged 4–5 and 6–10 years old, frequency of arousal and apnea (p = 0.045 and p = 0.01, respectively) were higher in children with DS than in CC. Multivariate analyses showed that DS was associated with SDB-related signs and symptoms, estimated SDB, 3% ODI, average oxygen saturation (SpO2), and nadir SpO2, while USPs were associated only with higher values of SpO2 <90%. Conclusions: Estimated SDB tended to increase in children with DS but decreased in CC with growth. USPs were more frequent in children with DS than in CC, especially in older children. USPs might indicate severe hypoxemia due to SDB in DS.

Original languageEnglish
Article number100045
JournalSleep Medicine: X
Publication statusPublished - Dec 2022

All Science Journal Classification (ASJC) codes

  • Medicine(all)


Dive into the research topics of 'Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children'. Together they form a unique fingerprint.

Cite this