TY - JOUR
T1 - Characteristics of patients with liver cancer in the BioBank Japan project
AU - Biobank Japan Cooperative Hospital Group
AU - Ukawa, Shigekazu
AU - Okada, Emiko
AU - Nakamura, Koshi
AU - Hirata, Makoto
AU - Nagai, Akiko
AU - Matsuda, Koichi
AU - Yamagata, Zentaro
AU - Kamatani, Yoichiro
AU - Ninomiya, Toshiharu
AU - Kiyohara, Yutaka
AU - Muto, Kaori
AU - Kubo, Michiaki
AU - Nakamura, Yusuke
AU - Tamakoshi, Akiko
AU - Harada, Hiromasa
AU - Kaneko, Kiyoshi
AU - Matsumoto, Shuichi
AU - Shiono, Masaki
AU - Minami, Shiro
AU - Yoshida, Hiroshi
AU - Taniai, Nobuhiko
AU - Watanabe, Sumio
AU - Fujiwara, Noriko
AU - Yamataka, Atsuyuki
AU - Asai, Satoshi
AU - Moriyama, Mitsuhiko
AU - Takahashi, Yasuo
AU - Fujioka, Tomoaki
AU - Obara, Wataru
AU - Mori, Seijiro
AU - Ito, Hideki
AU - Nagayama, Satoshi
AU - Miki, Yoshio
AU - Masumoto, Akihide
AU - Yamada, Akira
AU - Nishizawa, Yasuko
AU - Kodama, Ken
AU - Naka, Shigeyuki
AU - Endo, Yoshihiro
AU - Koretsune, Yukihiro
AU - Mita, Eiji
AU - Morimoto, Kozo
N1 - Funding Information:
We express our gratitude to all the participants in the BioBank Japan Project. We thank all the medical coordinators of the cooperating hospitals for collecting samples and clinical information, as well as Yasushi Yamashita and staff members of the BioBank Japan Project for administrative support. We also thank Dr. Kumao Toyoshima for his overall supervision of the BioBank Japan project. This study was supported by funding from the Tailor-Made Medical Treatment with the BBJ Project from Japan Agency for Medical Research and development, AMED (since April 2015), and the Ministry of Education, Culture, Sports, Science, and Technology (from April 2003 to March 2015).
Publisher Copyright:
© 2017 The Authors.
PY - 2017
Y1 - 2017
N2 - Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the menwas overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.
AB - Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the menwas overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.
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U2 - 10.1016/j.je.2016.12.007
DO - 10.1016/j.je.2016.12.007
M3 - Article
C2 - 28214185
AN - SCOPUS:85016400213
SN - 0917-5040
VL - 27
SP - S43-S48
JO - Journal of epidemiology
JF - Journal of epidemiology
IS - 3
ER -
