TY - JOUR
T1 - Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries
T2 - An Asian Network for Surveillance of Resistant Pathogens (ANSORP) study
AU - Kim, So Hyun
AU - Song, Jae Hoon
AU - Chung, Doo Ryeon
AU - Thamlikitkul, Visanu
AU - Yang, Yonghong
AU - Wang, Hui
AU - Lu, Min
AU - So, Thomas Man Kit
AU - Hsueh, Po Ren
AU - Yasin, Rohani M.
AU - Carlos, Celia C.
AU - Van Pham, Hung
AU - Lalitha, M. K.
AU - Shimono, Nobuyuki
AU - Perera, Jennifer
AU - Shibl, Atef M.
AU - Baek, Jin Yang
AU - Kang, Cheol In
AU - Ko, Kwan Soo
AU - Peck, Kyong Ran
PY - 2012/3
Y1 - 2012/3
N2 - Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Asian Network for Surveillance of Resistant Pathogens (ANSORP) performed a prospective surveillance study of 2,184 S. pneumoniae isolates collected from patients with pneumococcal infections from 60 hospitals in 11 Asian countries from 2008 to 2009. Among nonmeningeal isolates, the prevalence rate of penicillin- nonsusceptible pneumococci (MIC,≥4 μg/ml) was 4.6% and penicillin resistance (MIC,≥8 μg/ml) was extremely rare (0.7%). Resistance to erythromycin was very prevalent in the region (72.7%); the highest rates were in China (96.4%), Taiwan (84.9%), and Vietnam (80.7%). Multidrug resistance (MDR) was observed in 59.3% of isolates from Asian countries. Major serotypes were 19F (23.5%), 23F (10.0%), 19A (8.2%), 14 (7.3%), and 6B (7.3%). Overall, 52.5% of isolates showed PCV7 serotypes, ranging from 16.1% in Philippines to 75.1% in Vietnam. Serotypes 19A (8.2%), 3 (6.2%), and 6A (4.2%) were the most prominent non-PCV7 serotypes in the Asian region. Among isolates with serotype 19A, 86.0% and 79.8% showed erythromycin resistance and MDR, respectively. The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A.
AB - Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Asian Network for Surveillance of Resistant Pathogens (ANSORP) performed a prospective surveillance study of 2,184 S. pneumoniae isolates collected from patients with pneumococcal infections from 60 hospitals in 11 Asian countries from 2008 to 2009. Among nonmeningeal isolates, the prevalence rate of penicillin- nonsusceptible pneumococci (MIC,≥4 μg/ml) was 4.6% and penicillin resistance (MIC,≥8 μg/ml) was extremely rare (0.7%). Resistance to erythromycin was very prevalent in the region (72.7%); the highest rates were in China (96.4%), Taiwan (84.9%), and Vietnam (80.7%). Multidrug resistance (MDR) was observed in 59.3% of isolates from Asian countries. Major serotypes were 19F (23.5%), 23F (10.0%), 19A (8.2%), 14 (7.3%), and 6B (7.3%). Overall, 52.5% of isolates showed PCV7 serotypes, ranging from 16.1% in Philippines to 75.1% in Vietnam. Serotypes 19A (8.2%), 3 (6.2%), and 6A (4.2%) were the most prominent non-PCV7 serotypes in the Asian region. Among isolates with serotype 19A, 86.0% and 79.8% showed erythromycin resistance and MDR, respectively. The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A.
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U2 - 10.1128/AAC.05658-11
DO - 10.1128/AAC.05658-11
M3 - Article
C2 - 22232285
AN - SCOPUS:84863115207
SN - 0066-4804
VL - 56
SP - 1418
EP - 1426
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 3
ER -