Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study

Hiroshi Tateishi, Daiki Setoyama, Takahiro A. Kato, Dongchon Kang, Jun Matsushima, Kojiro Nogami, Seiji Mawatari, Ryohei Kojima, Yuka Fujii, Yuta Sakemura, Takumi Shiraishi, Yoshiomi Imamura, Toshihiko Maekawa, Toyoko Asami, Yoshito Mizoguchi, Akira Monji

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms in treatment-resistant depression (TRD). This study aimed to analyze changes in cerebrospinal fluid (CSF) metabolites in patients with TRD after rTMS. Five patients with TRD were enrolled in a high frequency (10-Hz) rTMS study. The concentration of 72 CSF metabolites were measured at baseline and at the end of the 6-week rTMS treatment. rTMS significantly increased CSF niacinamide, kynurenine, and creatinine levels and significantly decreased CSF cystine levels, but not the levels of the other 68 CSF metabolites. This is the first CSF metabolomics study on patients with TRD who underwent rTMS.

Original languageEnglish
Article number114636
JournalPsychiatry research
Volume313
DOIs
Publication statusPublished - Jul 2022

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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