TY - JOUR
T1 - Changes in estrogen receptors α and β expression in the brain of mice exposed prenatally to bisphenol A
AU - Kawai, Keisuke
AU - Murakami, Shuji
AU - Senba, Emiko
AU - Yamanaka, Takeharu
AU - Fujiwara, Yuya
AU - Arimura, Chikako
AU - Nozaki, Takehiro
AU - Takii, Masato
AU - Kubo, Chiharu
N1 - Funding Information:
This work was supported by CREST, JST (Japan Science and Technology). We are grateful to the staff of the animal colony of Kyushu University for their assistance with the experimental mice. Furthermore, we are grateful to Mrs. Yukiko Miyase for her technical and secretarial assistance.
PY - 2007/3
Y1 - 2007/3
N2 - The expression of ERs α and β and serotonergic neurons were evaluated in the brains of mice prenatally exposed to Bisphenol A, a known endocrine disrupting chemical (EDc). Bisphenol A was administered orally at a dose of 2 ng/g body weight on gestinational days 11-17 to pregnant ICR mice. Newborn male offspring (Bis-A mice) were evaluated for the immunoreactivity of ERs α and β, serotonin, and serotonin transporter positive cells in the dorsal raphe nucleus (DRN). The serum testosterone level was also evaluated. In the Bis-A mice, the expression of ERs α and β at 5 and 13 weeks was increased compared with the controls (P < 0.04), but this difference disappeared by the 9th week. The serotonin, serotonin transporter, and testosterone level differences between two groups did not reach significance. Exposure to bisphenol A may have changed the expression of ERs in the brain, but did not directly affect serotonin neurons in the DRN.
AB - The expression of ERs α and β and serotonergic neurons were evaluated in the brains of mice prenatally exposed to Bisphenol A, a known endocrine disrupting chemical (EDc). Bisphenol A was administered orally at a dose of 2 ng/g body weight on gestinational days 11-17 to pregnant ICR mice. Newborn male offspring (Bis-A mice) were evaluated for the immunoreactivity of ERs α and β, serotonin, and serotonin transporter positive cells in the dorsal raphe nucleus (DRN). The serum testosterone level was also evaluated. In the Bis-A mice, the expression of ERs α and β at 5 and 13 weeks was increased compared with the controls (P < 0.04), but this difference disappeared by the 9th week. The serotonin, serotonin transporter, and testosterone level differences between two groups did not reach significance. Exposure to bisphenol A may have changed the expression of ERs in the brain, but did not directly affect serotonin neurons in the DRN.
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U2 - 10.1016/j.yrtph.2006.04.002
DO - 10.1016/j.yrtph.2006.04.002
M3 - Article
C2 - 17222491
AN - SCOPUS:33846799093
SN - 0273-2300
VL - 47
SP - 166
EP - 170
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
IS - 2
ER -