TY - JOUR
T1 - Changes in chorioretinal blood flow velocity and cerebral blood flow after carotid endarterectomy
AU - Enaida, Hiroshi
AU - Nagata, Shinji
AU - Takeda, Atsunobu
AU - Nakao, Shintaro
AU - Ikeda, Yasuhiro
AU - Ishibashi, Tatsuro
N1 - Funding Information:
We thank Masatou Kawashima, M.D. (Department of Neurosurgery, Saga University, Saga, Japan), and Sei Haga, M.D. (Department of Neurosurgery, Kyushu Rosai Hospital, Fukuoka, Japan), for advice on SPECT. This work was supported in part by a grant from the Japan Medical Association and by grant-in-aid #15K10897 for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology.
Publisher Copyright:
© 2016, Japanese Ophthalmological Society.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Purpose: To investigate the changes in chorioretinal blood flow velocity and cerebral blood after carotid endarterectomy (CEA). Methods: Nine patients with moderate to severe internal carotid artery stenosis underwent CEA. Chorioretinal blood flow velocity was measured by laser speckle flowgraphy (LSFG), while cerebral blood flow (CBF) was measured by single-photon emission computed tomography (SPECT), on the affected side both before and after CEA. LSFG was evaluated in five areas to determine mean blur rate, while CBF was calculated from regional CBF and cerebrovascular reactivity (CVR), at the middle cerebral artery (MCA) region of each patient. Results: Five cases showed an increase (mean 3.49 %, range −29.82 to 35.59 %) of average chorioretinal blood flow velocity using LSFG after CEA. A particularly averaged increase in chorioretinal blood flow was observed in the macular area compared with other areas. Similarly, there was an increase in CBF at rest (mean 11.46 %, range −14.51 to 74.14 %) observed using SPECT after surgery. Improvement of CVR was confirmed in four cases. All general and visual symptoms disappeared after CEA. Severe adverse effects, including hyperperfusion syndrome, were not observed in any cases. Conclusions: LSFG may be useful for the analysis of chorioretinal blood flow changes after CEA.
AB - Purpose: To investigate the changes in chorioretinal blood flow velocity and cerebral blood after carotid endarterectomy (CEA). Methods: Nine patients with moderate to severe internal carotid artery stenosis underwent CEA. Chorioretinal blood flow velocity was measured by laser speckle flowgraphy (LSFG), while cerebral blood flow (CBF) was measured by single-photon emission computed tomography (SPECT), on the affected side both before and after CEA. LSFG was evaluated in five areas to determine mean blur rate, while CBF was calculated from regional CBF and cerebrovascular reactivity (CVR), at the middle cerebral artery (MCA) region of each patient. Results: Five cases showed an increase (mean 3.49 %, range −29.82 to 35.59 %) of average chorioretinal blood flow velocity using LSFG after CEA. A particularly averaged increase in chorioretinal blood flow was observed in the macular area compared with other areas. Similarly, there was an increase in CBF at rest (mean 11.46 %, range −14.51 to 74.14 %) observed using SPECT after surgery. Improvement of CVR was confirmed in four cases. All general and visual symptoms disappeared after CEA. Severe adverse effects, including hyperperfusion syndrome, were not observed in any cases. Conclusions: LSFG may be useful for the analysis of chorioretinal blood flow changes after CEA.
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U2 - 10.1007/s10384-016-0472-y
DO - 10.1007/s10384-016-0472-y
M3 - Article
C2 - 27566185
AN - SCOPUS:84983782693
SN - 0021-5155
VL - 60
SP - 459
EP - 465
JO - Japanese Journal of Ophthalmology
JF - Japanese Journal of Ophthalmology
IS - 6
ER -