Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor

Takuro Niidome; Nobukatsu Chijiiwa; Toshihide Yamasaki; Ken Ichi Yamada; Takeshi Mori; Tatsuya Naganuma; Hideo Utsumi; Kazuhiro Ichikawa; Yoshiki Katayama

doi:10.1246/cl.140209

Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor

Takuro Niidome, Nobukatsu Chijiiwa, Toshihide Yamasaki, Ken Ichi Yamada, Takeshi Mori, Tatsuya Naganuma, Hideo Utsumi, Kazuhiro Ichikawa, Yoshiki Katayama

Molecular Bioinformatics

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through the substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the Overhauser-enhanced MRI (OMRI) signal from the radicals. This system could be the basis of a functional tumor-imaging technique by OMRI.

Original language	English
Pages (from-to)	999-1001
Number of pages	3
Journal	Chemistry Letters
Volume	43
Issue number	7
DOIs	https://doi.org/10.1246/cl.140209
Publication status	Published - 2014

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.140209

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title = "Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor",

abstract = "Dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through the substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the Overhauser-enhanced MRI (OMRI) signal from the radicals. This system could be the basis of a functional tumor-imaging technique by OMRI.",

author = "Takuro Niidome and Nobukatsu Chijiiwa and Toshihide Yamasaki and Yamada, {Ken Ichi} and Takeshi Mori and Tatsuya Naganuma and Hideo Utsumi and Kazuhiro Ichikawa and Yoshiki Katayama",

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doi = "10.1246/cl.140209",

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T1 - Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor

AU - Niidome, Takuro

AU - Chijiiwa, Nobukatsu

AU - Yamasaki, Toshihide

AU - Yamada, Ken Ichi

AU - Mori, Takeshi

AU - Naganuma, Tatsuya

AU - Utsumi, Hideo

AU - Ichikawa, Kazuhiro

AU - Katayama, Yoshiki

PY - 2014

Y1 - 2014

N2 - Dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through the substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the Overhauser-enhanced MRI (OMRI) signal from the radicals. This system could be the basis of a functional tumor-imaging technique by OMRI.

AB - Dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through the substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the Overhauser-enhanced MRI (OMRI) signal from the radicals. This system could be the basis of a functional tumor-imaging technique by OMRI.

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DO - 10.1246/cl.140209

M3 - Article

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JO - Chemistry Letters

JF - Chemistry Letters

IS - 7

ER -

Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor

Abstract

All Science Journal Classification (ASJC) codes

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