Central nervous system involvement in adult T‐cell leukemia/lymphoma

Takanori Teshima, Koichi Akashi, Tsunefumi Shibuya, Shuichi Taniguchi, Takashi Okamura, Mine Harada, Ikuo Sumida, Motosuke Hanada, Yoshiyuki Niho

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88 Citations (Scopus)


Central nervous system (CNS) involvement was reviewed in 99 patients with adult T‐cell leukemia/lymphoma (ATLL). Fifteen episodes of CNS involvement developed in ten of 99 patients (10.1%); nine had leptomeningeal involvement, whereas two developed intracerebral invasion, one developed cord involvement, and one developed both. CNS involvement was more frequent in the lymphoma type than in the other types of ATLL. Nuchal rigidity was not common (33%) and a syndrome of inappropriate secretion of antidiuretic hormone (ADH) occurred in association with CNS involvement (40%). Three episodes of marked hypoglycorrhachia also were noticed. The systemic progression of ATLL was the most common setting of CNS involvement (80%) and the major cause of death (80%). As for the acute and lymphoma types of ATLL, no significant difference was observed in survival between patients with and those without CNS involvement. These results indicate that CNS involvement is not an essential prognostic factor of ATLL and that it should be treated with systemic chemotherapy coupled with intrathecal chemotherapy. The control of systemic ATLL is important for the prophylaxis of CNS involvement.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
Issue number2
Publication statusPublished - Jan 15 1990

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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