TY - JOUR
T1 - Central ghrelin acts as an anti-dipsogenic peptide in chicks
AU - Tachibana, Tetsuya
AU - Kaiya, Hiroyuki
AU - Denbow, D. Michael
AU - Kangawa, Kenji
AU - Furuse, Mitsuhiro
N1 - Funding Information:
We are grateful to Daichi Oikawa and Nami Adachi, Kyushu University, Japan, for their help in the present study. We thank Daiichi-Suntory Pharmaceutical Co. Ltd. (now named Daiichi Asubio Pharma Co. Ltd.) for synthesizing chicken ghrelin. This work was supported by a Grant-in-Aid for Young Scientists (No. 15780187) from Japan Society for the Promotion of Science (JSPS) and a Grant-in-Aid for Scientific Research from JSPS (Nos. 16380191, 17208023 and 18208023).
PY - 2006/9/25
Y1 - 2006/9/25
N2 - The aim of this study was to look at whether ghrelin has an anti-dipsogenic effect, as seen in the eel, when administered centrally in neonatal chicks. Intracerebroventricular (ICV) injection of chicken ghrelin inhibited water intake (WI) in chicks under both ad libitum and 17-h water-deprived drinking conditions at doses ranging from 0.01 to 0.1 nmol/chick. This inhibitory effect was observed when 0.1 nmol of rat ghrelin was injected. On the other hand, 0.1 nmol des-acyl rat ghrelin did not reduce WI. To examine the mechanism underlying the effect of ghrelin on WI, chicken B-type (or brain) natriuretic peptide (BNP), an anti-dipsogenic peptide in mammals, was injected at doses ranging from 0.1 to 1 nmol/chick. BNP did not affect WI in chicks under both normal and water-deprived drinking conditions. These findings indicate that ghrelin acts as an anti-dipsogenic peptide through the GHS receptor in the chicken.
AB - The aim of this study was to look at whether ghrelin has an anti-dipsogenic effect, as seen in the eel, when administered centrally in neonatal chicks. Intracerebroventricular (ICV) injection of chicken ghrelin inhibited water intake (WI) in chicks under both ad libitum and 17-h water-deprived drinking conditions at doses ranging from 0.01 to 0.1 nmol/chick. This inhibitory effect was observed when 0.1 nmol of rat ghrelin was injected. On the other hand, 0.1 nmol des-acyl rat ghrelin did not reduce WI. To examine the mechanism underlying the effect of ghrelin on WI, chicken B-type (or brain) natriuretic peptide (BNP), an anti-dipsogenic peptide in mammals, was injected at doses ranging from 0.1 to 1 nmol/chick. BNP did not affect WI in chicks under both normal and water-deprived drinking conditions. These findings indicate that ghrelin acts as an anti-dipsogenic peptide through the GHS receptor in the chicken.
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U2 - 10.1016/j.neulet.2006.07.019
DO - 10.1016/j.neulet.2006.07.019
M3 - Article
C2 - 16901639
AN - SCOPUS:33746902373
SN - 0304-3940
VL - 405
SP - 241
EP - 245
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -