TY - JOUR
T1 - Central, but not peripheral, glucagon-like peptide-1 inhibits crop emptying in chicks
AU - Tachibana, Tetsuya
AU - Matsumoto, Mako
AU - Furuse, Mitsuhiro
AU - Hasegawa, Shin
AU - Yoshizawa, Fumiaki
AU - Sugahara, Kunio
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - We investigated the effect of central and peripheral glucagon-like peptide-1 (GLP-1) on crop emptying in growing chicks. Intracerebroventricular injection of two concentrations of GLP-1 (15 and 60 pmol) similarly suppressed crop emptying, compared with control chicks. The delay in crop emptying induced by GLP-1 (15 pmol) was partly attenuated by co-administration with exendin (5-39) (600 pmol), a GLP-1 receptor antagonist, although exendin (5-39) alone did not affect crop emptying. On the other hand, intraperitoneal administration of several doses of GLP-1 (120, 300 and 3000 pmol) did not alter crop emptying. The present study revealed that central, but not peripheral, GLP-1 inhibits crop emptying in chicks.
AB - We investigated the effect of central and peripheral glucagon-like peptide-1 (GLP-1) on crop emptying in growing chicks. Intracerebroventricular injection of two concentrations of GLP-1 (15 and 60 pmol) similarly suppressed crop emptying, compared with control chicks. The delay in crop emptying induced by GLP-1 (15 pmol) was partly attenuated by co-administration with exendin (5-39) (600 pmol), a GLP-1 receptor antagonist, although exendin (5-39) alone did not affect crop emptying. On the other hand, intraperitoneal administration of several doses of GLP-1 (120, 300 and 3000 pmol) did not alter crop emptying. The present study revealed that central, but not peripheral, GLP-1 inhibits crop emptying in chicks.
UR - http://www.scopus.com/inward/record.url?scp=0038278681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038278681&partnerID=8YFLogxK
U2 - 10.1016/S1095-6433(03)00009-6
DO - 10.1016/S1095-6433(03)00009-6
M3 - Article
C2 - 12814786
AN - SCOPUS:0038278681
SN - 1095-6433
VL - 134
SP - 777
EP - 781
JO - Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
JF - Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
IS - 4
ER -