Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks

Tomoyuki Koutoku, Hirokazu Takahashi, Shozo Tomonaga, Daichi Oikawa, Shin Saito, Tetsuya Tachibana, Li Han, Kohsuke Hayamizu, D. Michael Denbow, Mitsuhiro Furuse

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53 Citations (Scopus)


The present study investigated whether centrally administered phosphatidylserine (PS) could modify the behavior of chicks under isolation-induced stress. Isolation stress-induced vocalization and spontaneous activity for 10 min, which were attenuated by intracerebroventricular (i.c.v.) injection of PS. The effect of PS was compared with other phospholipids or l-serine, a constituent of PS. Phosphatidylcholine (PC) had no effect on these behavior, but phosphatidylethanolamine (PE) significantly increased vocalizations and spontaneous activity compared with PS. l-Serine similarly decreased isolation-induced vocalizations and spontaneous activity. To clarify the mechanism by which central PS attenuates isolation-induced stress behavior, the contribution of the acetylcholine (ACh) receptor (AChR) was also investigated. PS was co-injected i.c.v. with the muscarinic AChR (M-AChR) antagonist scopolamine or the nicotinic AChR (N-AChR) antagonist hexamethonium. The suppression of vocalizations and spontaneous activity by PS was partially attenuated by scopolamine, but not hexamethonium. These findings indicate that isolation-induced stress behavior are attenuated by PS, acting partially through the M-AChR.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalNeurochemistry International
Issue number3
Publication statusPublished - Aug 2005

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology


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