Central administration of alpha-melanocyte-stimulating hormone changes lipid metabolism in chicks

Tetsuya Tachibana, Daichi Oikawa, Nami Adachi, Tim Boswell, Mitsuhiro Furuse

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Alpha-melanocyte-stimulating hormone (MSH) is well known as an anorexigenic peptide in the brain of mammals. In addition to this, brain alpha-MSH enhances heat production (HP), indicating that the peptide acts as a catabolic factor in the regulation of energy metabolism. The anorexigenic effect of alpha-MSH is also observed in chicks (Gallus gallus), but no information has been available for its effect on HP. The present study was performed to examine whether intracerebroventricular (ICV) injection of alpha-MSH increases HP in chicks. The injection of alpha-MSH (10 and 100 pmol) did not affect oxygen consumption, carbon dioxide production and HP during the 1 h post-injection period. This result was supported by another result that ICV injection of alpha-MSH did not affect locomotion activity in chicks. In contrast, the respiratory quotient was significantly lowered by the ICV injection of MSH. We also found that alpha-MSH significantly increased plasma non-esterified fatty acid concentrations. In summary, brain alpha-MSH appears to exert generally catabolic effects on lipid metabolism in the chick, but does not appear to be involved in the regulation of HP.

Original languageEnglish
Pages (from-to)408-412
Number of pages5
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Issue number2
Publication statusPublished - Oct 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology


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