Central administration of α-melanocyte stimulating hormone inhibits fasting- and neuropeptide Y-induced feeding in neonatal chicks

Shin Ichi Kawakami; Takashi Bungo; Ryuichi Ando; Atsushi Ohgushi; Masataka Shimojo; Yasuhisa Masuda; Mitsuhiro Furuse

doi:10.1016/S0014-2999(00)00344-7

Central administration of α-melanocyte stimulating hormone inhibits fasting- and neuropeptide Y-induced feeding in neonatal chicks

Shin Ichi Kawakami, Takashi Bungo, Ryuichi Ando, Atsushi Ohgushi, Masataka Shimojo, Yasuhisa Masuda, Mitsuhiro Furuse

Animal and Marine Bioresource Sciences

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

In the present study, the effect of intracerebroventricular (i.c.v.) administration of α-melanocyte stimulating hormone (α-MSH) on food intake of neonatal chicks was examined. In experiment 1, i.c.v. injection of α-MSH (0.04, 0.2 and 1 μg) significantly inhibited food intake of 3-h fasted chicks in a dose-dependent manner. In experiment 2, α-MSH strongly inhibited neuropeptide Y-induced feeding when neuropeptide Y (2.5 μg) and several doses of α-MSH were given simultaneously i.c.v. These results suggest that α-MSH plays an important role in the regulation of food intake of neonatal chicks. Copyright (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	361-364
Number of pages	4
Journal	European Journal of Pharmacology
Volume	398
Issue number	3
DOIs	https://doi.org/10.1016/S0014-2999(00)00344-7
Publication status	Published - Jun 23 2000

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1016/S0014-2999(00)00344-7

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@article{ba6516fd2bd54fca9f0ff621af519b4e,

title = "Central administration of α-melanocyte stimulating hormone inhibits fasting- and neuropeptide Y-induced feeding in neonatal chicks",

abstract = "In the present study, the effect of intracerebroventricular (i.c.v.) administration of α-melanocyte stimulating hormone (α-MSH) on food intake of neonatal chicks was examined. In experiment 1, i.c.v. injection of α-MSH (0.04, 0.2 and 1 μg) significantly inhibited food intake of 3-h fasted chicks in a dose-dependent manner. In experiment 2, α-MSH strongly inhibited neuropeptide Y-induced feeding when neuropeptide Y (2.5 μg) and several doses of α-MSH were given simultaneously i.c.v. These results suggest that α-MSH plays an important role in the regulation of food intake of neonatal chicks. Copyright (C) 2000 Elsevier Science B.V.",

author = "Kawakami, {Shin Ichi} and Takashi Bungo and Ryuichi Ando and Atsushi Ohgushi and Masataka Shimojo and Yasuhisa Masuda and Mitsuhiro Furuse",

note = "Funding Information: This study was supported by a grant-in-aid for scientific research from the Ministry of Education, Science and Culture, Japan.",

year = "2000",

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doi = "10.1016/S0014-2999(00)00344-7",

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T1 - Central administration of α-melanocyte stimulating hormone inhibits fasting- and neuropeptide Y-induced feeding in neonatal chicks

AU - Kawakami, Shin Ichi

AU - Bungo, Takashi

AU - Ando, Ryuichi

AU - Ohgushi, Atsushi

AU - Shimojo, Masataka

AU - Masuda, Yasuhisa

AU - Furuse, Mitsuhiro

N1 - Funding Information: This study was supported by a grant-in-aid for scientific research from the Ministry of Education, Science and Culture, Japan.

PY - 2000/6/23

Y1 - 2000/6/23

N2 - In the present study, the effect of intracerebroventricular (i.c.v.) administration of α-melanocyte stimulating hormone (α-MSH) on food intake of neonatal chicks was examined. In experiment 1, i.c.v. injection of α-MSH (0.04, 0.2 and 1 μg) significantly inhibited food intake of 3-h fasted chicks in a dose-dependent manner. In experiment 2, α-MSH strongly inhibited neuropeptide Y-induced feeding when neuropeptide Y (2.5 μg) and several doses of α-MSH were given simultaneously i.c.v. These results suggest that α-MSH plays an important role in the regulation of food intake of neonatal chicks. Copyright (C) 2000 Elsevier Science B.V.

AB - In the present study, the effect of intracerebroventricular (i.c.v.) administration of α-melanocyte stimulating hormone (α-MSH) on food intake of neonatal chicks was examined. In experiment 1, i.c.v. injection of α-MSH (0.04, 0.2 and 1 μg) significantly inhibited food intake of 3-h fasted chicks in a dose-dependent manner. In experiment 2, α-MSH strongly inhibited neuropeptide Y-induced feeding when neuropeptide Y (2.5 μg) and several doses of α-MSH were given simultaneously i.c.v. These results suggest that α-MSH plays an important role in the regulation of food intake of neonatal chicks. Copyright (C) 2000 Elsevier Science B.V.

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

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ER -

Central administration of α-melanocyte stimulating hormone inhibits fasting- and neuropeptide Y-induced feeding in neonatal chicks

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