TY - JOUR
T1 - Cellular response of sinorhizobium sp. Strain A2 during arsenite oxidation
AU - Fukushima, Koh
AU - Huang, He
AU - Hamamura, Natsuko
N1 - Publisher Copyright:
© 2015 Japanese Society of Microbial Ecology. All rights reserved.
PY - 2015/12/22
Y1 - 2015/12/22
N2 - Arsenic (As) is a widely distributed toxic element in the environment and microorganisms have developed resistance mechanisms in order to tolerate it. The cellular response of the chemoorganotrophic arsenite (As[III])-oxidizing α- Proteobacteria, Sinorhizobium sp. strain A2, to arsenic was examined in the present study. Several proteins associated with arsenite oxidase and As resistance were shown to be accumulated in the presence of As(III). A shift in central carbon metabolism from the tricarboxylic acid pathway to glyoxylate pathway was also observed in response to oxidative stress. Our results revealed the strategy of the As(III)-oxidizing Sinorhizobium strain to mitigate arsenic toxicity and oxidative damage by multiple metabolic adaptations.
AB - Arsenic (As) is a widely distributed toxic element in the environment and microorganisms have developed resistance mechanisms in order to tolerate it. The cellular response of the chemoorganotrophic arsenite (As[III])-oxidizing α- Proteobacteria, Sinorhizobium sp. strain A2, to arsenic was examined in the present study. Several proteins associated with arsenite oxidase and As resistance were shown to be accumulated in the presence of As(III). A shift in central carbon metabolism from the tricarboxylic acid pathway to glyoxylate pathway was also observed in response to oxidative stress. Our results revealed the strategy of the As(III)-oxidizing Sinorhizobium strain to mitigate arsenic toxicity and oxidative damage by multiple metabolic adaptations.
UR - http://www.scopus.com/inward/record.url?scp=84950978126&partnerID=8YFLogxK
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U2 - 10.1264/jsme2.ME15096
DO - 10.1264/jsme2.ME15096
M3 - Article
C2 - 26477790
AN - SCOPUS:84950978126
SN - 1342-6311
VL - 30
SP - 330
EP - 334
JO - Microbes and environments
JF - Microbes and environments
IS - 4
ER -