TY - JOUR
T1 - Cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)
AU - Fujihara, Kazuo
AU - Itoyama, Yasuto
AU - Yu, Feng
AU - Kubo, Chiharu
AU - Goto, Ikuo
N1 - Funding Information:
Acknowledgements We thank Dr. Y. Nishimura for helpful suggestions and discussion and B. Quinn for comments on the manuscript. This work was supported by a grant-in-aid for General Scientific Research (63480217), from the Ministry of Education, Science and Culture, and by grants from the Neuroimmunological Disease Research Committee and from the Slow Virus Infection Research Committee, the Ministry of Health and Welfare of Japan.
PY - 1991/9
Y1 - 1991/9
N2 - To investigate the cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied the cytotoxic T lymphocytes (CTL) activity against an HTLV-I infected human T cell line (MT-2) and the natural killer (NK) cell activity in 15 HAM patients, 6 HTLV-I carriers, and 15 controls. The activity of CTL against MT-2 cells was found to be significantly elevated in HAM compared with that in the controls. This cytotoxicity in HAM was higher than in HTLV-I carriers, although the difference was not statistically significant. There was an HLA class I restriction in this CTL activity against MT-2 cells in HAM. On the other hand, NK cell activity was significantly lower in HAM than in controls. Cold target inhibition studies suggested that NK cells could not lyse MT-2 cells effectively. There was a positive correlation between the CTL activity against MT-2 cells and the serum antibody titers to HTLV-I in HAM.
AB - To investigate the cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied the cytotoxic T lymphocytes (CTL) activity against an HTLV-I infected human T cell line (MT-2) and the natural killer (NK) cell activity in 15 HAM patients, 6 HTLV-I carriers, and 15 controls. The activity of CTL against MT-2 cells was found to be significantly elevated in HAM compared with that in the controls. This cytotoxicity in HAM was higher than in HTLV-I carriers, although the difference was not statistically significant. There was an HLA class I restriction in this CTL activity against MT-2 cells in HAM. On the other hand, NK cell activity was significantly lower in HAM than in controls. Cold target inhibition studies suggested that NK cells could not lyse MT-2 cells effectively. There was a positive correlation between the CTL activity against MT-2 cells and the serum antibody titers to HTLV-I in HAM.
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U2 - 10.1016/0022-510X(91)90125-Q
DO - 10.1016/0022-510X(91)90125-Q
M3 - Article
C2 - 1795176
AN - SCOPUS:0025818101
SN - 0022-510X
VL - 105
SP - 99
EP - 107
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1
ER -