TY - JOUR
T1 - Cellular behaviors on polymeric scaffolds with 2D-patterned mechanical properties
AU - Shimomura, Shinichiro
AU - Matsuno, Hisao
AU - Kinoshita, Yohei
AU - Fujimura, Satoshi
AU - Tanaka, Keiji
N1 - Funding Information:
Acknowledgements This research was partly supported by JSPS KAKENHI, Grant-in-Aid for Scientific Research (A) (No. JP15H02183) to KT and for Scientific Research (C) (JP15K05633) to HM. We are also grateful for support from the Development of Advanced Measurement and Analysis System Program (JST-SEN-TAN) (13A0004) by the Japan Science and Technology Agency (JST) to KT and Impulsing Paradigm Change through Disruptive Technologies Program (ImPACT) by the Cabinet Office, Government of Japan, to KT.
Publisher Copyright:
© 2018, The Society of Polymer Science, Japan.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - We propose a novel concept for cellular scaffolds with 2D-patterned mechanical properties. Thin films of glassy polystyrene (PS) with thicknesses ranging from 100 nm to 1 μm were prepared on epoxy resin-based line and space (L&S) patterned substrates. Although the outermost surface of PS on the L- and S-regions was sufficiently flat at the same level, the mechanical responses differed depending on the presence of the underlying resin foundation. The initial cell adhesion and spreading and the proliferation on the scaffolds were affected by the 2D-patterned mechanical properties, that is, cellular behavior was suppressed on mechanically unstable S-regions.
AB - We propose a novel concept for cellular scaffolds with 2D-patterned mechanical properties. Thin films of glassy polystyrene (PS) with thicknesses ranging from 100 nm to 1 μm were prepared on epoxy resin-based line and space (L&S) patterned substrates. Although the outermost surface of PS on the L- and S-regions was sufficiently flat at the same level, the mechanical responses differed depending on the presence of the underlying resin foundation. The initial cell adhesion and spreading and the proliferation on the scaffolds were affected by the 2D-patterned mechanical properties, that is, cellular behavior was suppressed on mechanically unstable S-regions.
UR - http://www.scopus.com/inward/record.url?scp=85045098012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045098012&partnerID=8YFLogxK
U2 - 10.1038/s41428-018-0043-9
DO - 10.1038/s41428-018-0043-9
M3 - Article
AN - SCOPUS:85045098012
SN - 0032-3896
VL - 50
SP - 737
EP - 743
JO - Polymer Journal
JF - Polymer Journal
IS - 8
ER -