Cell mechanical characterization based on on-chip robotics

Fumihito Arai, Shinya Sakuma

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


In this chapter, we propose “on-chip robotics” that is based on robot technologies and lab-on-a-chip devices to achieve high-speed, high-accuracy, and quantitative cell manipulation and analysis on a chip. We presents a high-throughput cell mechanical characterization method using a robot integrated microfluidic chip (robochip). The robochip contains a magnetically driven on-chip probe, a force sensor, and microchannels. The displacement reduction mechanism is adopted to the on-chip probe for high resolution positioning of the tip of the probe, and we achieved noncontact actuation of the on-chip probe with 0.18 μm in repetitive positioning. We show the automated mechanical characterization of oocyte. The throughput of the measurement is approximately 15–20 s per oocyte, and we conclude that high-throughput cellular mechanical characterization is achieved. We also show measurements of the viscoelastic properties of oocyte using the robochip. The proposed approach based on a robochip is a promising technology for contributing to the analysis of the physical and biological properties of cells.

Original languageEnglish
Title of host publicationHyper Bio Assembler for 3D Cellular Systems
PublisherSpringer Japan
Number of pages20
ISBN (Electronic)9784431552970
ISBN (Print)9784431552963
Publication statusPublished - Jan 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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