Cell Kinetics of Intracerebrally Implanted RG-C6 Tumors in Rats: Effects of Intracarotid Hyperosmolar Mannitol measured by 3H-thymidine Autoradiography and Bromodeoxyuridine Uptake

Tooru Inoue; Masashi Fukui; Iwao Takeshita; Toru Iwaki

doi:10.2176/nmc.28.533

Cell Kinetics of Intracerebrally Implanted RG-C6 Tumors in Rats: Effects of Intracarotid Hyperosmolar Mannitol measured by ³H-thymidine Autoradiography and Bromodeoxyuridine Uptake

Tooru Inoue, Masashi Fukui, Iwao Takeshita, Toru Iwaki

Department of Basic Medicine

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Abstract

The proliferative activity of intracerebrally implanted rat glioma C6 (RG-C6) tumors in rats was exam ined by means of ³H-thymidine autoradiography and measurement of bromodeoxyuridine (BrdU) uptake. The effect of intracarotid hyperosmolar mannitol on the cell kinetics of the RG-C6 tumors was studied by the latter method. The labeling index (LI) and distribution of ³H-thymidine-labeled cells were identical to those of the BrdU-labeled cells. The LIs of BrdU-labeled cells were not altered by in tracarotid mannitol injection. The influence of intracarotid hyperosmolar mannitol infusion not only on brain tumors but also on normal brain tissue is discussed.

Original language	English
Pages (from-to)	533-537
Number of pages	5
Journal	Neurologia medico-chirurgica
Volume	28
Issue number	6
DOIs	https://doi.org/10.2176/nmc.28.533
Publication status	Published - 1988

All Science Journal Classification (ASJC) codes

Surgery
Clinical Neurology

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Cell Kinetics of Intracerebrally Implanted RG-C6 Tumors in Rats: Effects of Intracarotid Hyperosmolar Mannitol measured by ³H-thymidine Autoradiography and Bromodeoxyuridine Uptake. / Inoue, Tooru; Fukui, Masashi; Takeshita, Iwao et al.
In: Neurologia medico-chirurgica, Vol. 28, No. 6, 1988, p. 533-537.

Research output: Contribution to journal › Article › peer-review

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abstract = "The proliferative activity of intracerebrally implanted rat glioma C6 (RG-C6) tumors in rats was exam ined by means of 3H-thymidine autoradiography and measurement of bromodeoxyuridine (BrdU) uptake. The effect of intracarotid hyperosmolar mannitol on the cell kinetics of the RG-C6 tumors was studied by the latter method. The labeling index (LI) and distribution of 3H-thymidine-labeled cells were identical to those of the BrdU-labeled cells. The LIs of BrdU-labeled cells were not altered by in tracarotid mannitol injection. The influence of intracarotid hyperosmolar mannitol infusion not only on brain tumors but also on normal brain tissue is discussed.",

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AB - The proliferative activity of intracerebrally implanted rat glioma C6 (RG-C6) tumors in rats was exam ined by means of 3H-thymidine autoradiography and measurement of bromodeoxyuridine (BrdU) uptake. The effect of intracarotid hyperosmolar mannitol on the cell kinetics of the RG-C6 tumors was studied by the latter method. The labeling index (LI) and distribution of 3H-thymidine-labeled cells were identical to those of the BrdU-labeled cells. The LIs of BrdU-labeled cells were not altered by in tracarotid mannitol injection. The influence of intracarotid hyperosmolar mannitol infusion not only on brain tumors but also on normal brain tissue is discussed.

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Cell Kinetics of Intracerebrally Implanted RG-C6 Tumors in Rats: Effects of Intracarotid Hyperosmolar Mannitol measured by ³H-thymidine Autoradiography and Bromodeoxyuridine Uptake

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