Cell adhesion to mixed self-assembled monolayers carrying different terminal functional groups

Yusuke Arima, Saori Fujimoto, Hiroo Iwata

Research output: Contribution to conferencePaperpeer-review


We examined relationship between wettability and cell adhesion by taking advantage of self-assembled monolayers (SAMs) of alkanethiols. The SAMs presenting a wide range of wettabilities were prepared by mixing two kinds of alkanethiols carrying terminal methyl (CH3), hydroxyl (OH), carboxylic acid (COOH), and amino groups (NH2). The adhesion of human umbilical vein endothelial cells (HUVEC) in a serum-containing medium was greatly influenced by surface functional groups on mixed SAMs: cells adhered to CH3/COOH and CH3/NH2 mixed SAMs with decreasing water contact angle, whereas cells adhered to CH3/OH mixed SAM showing the maximum at a water contact angle of around 40°. The surface plasmon resonance measurement showed that serum proteins from a culture medium adsorbed on all kinds of the mixed SAM surfaces examined, suggesting quantity, composition and conformation of underlying adsorbed protein layer determine cell adhesion to the surface.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006


Other55th SPSJ Annual Meeting

All Science Journal Classification (ASJC) codes

  • General Engineering


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