TY - GEN
T1 - Cell adhesion and migration in response to nano-patterned surfaces formed by diblock copolymers
AU - Khor, H. L.
AU - Kuan, Y. J.
AU - Hutmacher, D. W.
AU - Tamada, K.
AU - Knoll, W.
PY - 2004
Y1 - 2004
N2 - The cell adhesion and migration behavior on different nanopatterned surfaces was investigated to determine the effect of different nano-topography on cell function. The adsorption of extracellular matrix protein like fibronectin, on different nanopatterned surfaces, was performed by using immunofluorescence and contact angle measurements. The initial cell adhesion strength on the different substrates was studied by the use of laser tweezers. The live imaging of cell migration on the different substrates with cells transfected with EYFP-alpha-tubulin vector was studied. The initial cell culture on coated and plain mica strips demonstrated that hMSC displayed more of a polar morphology with long filopodium extensions on worm-like patterned substrates.
AB - The cell adhesion and migration behavior on different nanopatterned surfaces was investigated to determine the effect of different nano-topography on cell function. The adsorption of extracellular matrix protein like fibronectin, on different nanopatterned surfaces, was performed by using immunofluorescence and contact angle measurements. The initial cell adhesion strength on the different substrates was studied by the use of laser tweezers. The live imaging of cell migration on the different substrates with cells transfected with EYFP-alpha-tubulin vector was studied. The initial cell culture on coated and plain mica strips demonstrated that hMSC displayed more of a polar morphology with long filopodium extensions on worm-like patterned substrates.
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M3 - Conference contribution
AN - SCOPUS:13844298320
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
SP - 383
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -