Cdh1 is an antagonist of the spindle assembly checkpoint

Masayoshi Nagai, Takashi Ushimaru

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The spindle assembly checkpoint (SAC) monitors unsatisfied connections of microtubules to kinetochores and prevents anaphase onset by inhibition of the ubiquitin ligase E3 anaphase-promoting complex or cyclosome (APC/C) in association with the activator Cdc20. Another APC/C activator, Cdh1, exists permanently throughout the cell cycle but it becomes active from telophase to G1. Here, we show that Cdh1 is partially active and mediates securin degradation even in SAC-active metaphase cells. Additionally, Cdh1 mediates Cdc20 degradation in metaphase, promoting formation of the APC/C-Cdh1. These results indicate that Cdh1 opposes the SAC and promotes anaphase transition.

Original languageEnglish
Pages (from-to)2217-2222
Number of pages6
JournalCellular Signalling
Issue number10
Publication statusPublished - Oct 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology


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