TY - JOUR
T1 - Causes of death in patients undergoing maintenance hemodialysis in Japan
T2 - 10-year outcomes of the Q-Cohort Study
AU - Hiyamuta, Hiroto
AU - Yamada, Shunsuke
AU - Taniguchi, Masatomo
AU - Nakano, Toshiaki
AU - Tsuruya, Kazuhiko
AU - Kitazono, Takanari
N1 - Funding Information:
This study was supported by the Kidney Foundation (H19 JKFB 07–13, H20 JKFB 08–8, H23 JKFB 11–11) and the Japan Dialysis Outcome Research Foundation (H19-076–02, H20-003). The funders of this study had no role in study design including collection, analysis, and interpretation of data; writing of the report; or the decision to submit the report for publication. The authors declare that they have no relevant financial interests.
Publisher Copyright:
© 2021, Japanese Society of Nephrology.
PY - 2021/10
Y1 - 2021/10
N2 - Background: Although the mortality rate in patients on hemodialysis remains extremely high, detailed information on causes of death over long-term periods is limited. The aim of this study was to clarify the underlying causes of death in patients undergoing maintenance hemodialysis in Japan. Methods: This was a 10-year, multicenter, observational study of 3528 outpatients undergoing maintenance hemodialysis in Japan. Clinical outcomes were analyzed and causes of death were classified into six broad categories including cardiovascular diseases, infectious diseases, malignant neoplasms, cachexia, trauma/accidents, and other diseases, and more detailed subcategories. Results: During the 10-year follow-up period, 1748 (49.5%) patients died. The most frequent causes of death were cardiovascular diseases (36.1%), followed by infectious diseases (25.8%) and malignant neoplasms (13.5%). In a detailed classification, sudden death, pulmonary infection, and lung cancer were the most common causes of death in cardiovascular diseases, infectious diseases, and malignant neoplasms, respectively. Conclusion: Our study determined details on causes of death in Japanese hemodialysis patients during the 10-year follow-up period. Cardiovascular disease, especially sudden death is noticeable cause of death among patients on hemodialysis.
AB - Background: Although the mortality rate in patients on hemodialysis remains extremely high, detailed information on causes of death over long-term periods is limited. The aim of this study was to clarify the underlying causes of death in patients undergoing maintenance hemodialysis in Japan. Methods: This was a 10-year, multicenter, observational study of 3528 outpatients undergoing maintenance hemodialysis in Japan. Clinical outcomes were analyzed and causes of death were classified into six broad categories including cardiovascular diseases, infectious diseases, malignant neoplasms, cachexia, trauma/accidents, and other diseases, and more detailed subcategories. Results: During the 10-year follow-up period, 1748 (49.5%) patients died. The most frequent causes of death were cardiovascular diseases (36.1%), followed by infectious diseases (25.8%) and malignant neoplasms (13.5%). In a detailed classification, sudden death, pulmonary infection, and lung cancer were the most common causes of death in cardiovascular diseases, infectious diseases, and malignant neoplasms, respectively. Conclusion: Our study determined details on causes of death in Japanese hemodialysis patients during the 10-year follow-up period. Cardiovascular disease, especially sudden death is noticeable cause of death among patients on hemodialysis.
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U2 - 10.1007/s10157-021-02089-6
DO - 10.1007/s10157-021-02089-6
M3 - Article
C2 - 34100165
AN - SCOPUS:85107563228
SN - 1342-1751
VL - 25
SP - 1121
EP - 1130
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 10
ER -
