Cationic comb-type copolymers for boosting DNA-fueled nanomachines

Sung Won Choi, Naoki Makita, Satoru Inoue, Charles Lesoil, Asako Yamayoshi, Arihiro Kano, Toshihiro Akaike, Atsushi Maruyama

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


For the better applications and developments of DNA nanomachines, their responding kinetics, output, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in operating conditions. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces the robust and quick responses of DNA nanomachines under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nanomoles per liter range) through hybrid stabilization and DNA strand exchange acceleration.

Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalNano Letters
Issue number1
Publication statusPublished - Jan 2007

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Mechanical Engineering
  • Bioengineering
  • General Chemistry
  • General Materials Science


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