@article{42f16c5eaf404534adc6b2c2edb05a84,
title = "Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines",
abstract = "The first catalytic enantioselective decarboxylative Mannich-type reaction of N-unprotected ketimines is reported, directly providing N-unprotected 3-tetrasubstituted 3-aminooxindoles in high yield and ee without protection/deprotection steps. The utility of this reaction is demonstrated in the short step synthesis of (+)-AG-041R.",
author = "Masanao Sawa and Shotaro Miyazaki and Ryohei Yonesaki and Hiroyuki Morimoto and Takashi Ohshima",
note = "Funding Information: This work was supported by Grant-in-Aid for Scientific Research on Innovative Areas (JSPS KAKENHI Grant Number JP15H05846 in Middle Molecular Strategy for T.O.) and Grant-in-Aid for Scientific Research (B) (JSPS KAKENHI Grant Number JP17H03972 for T.O.) and (C) (JSPS KAKENHI Grant Numbers JP15K07860 and JP18K06581 for H.M.) from JSPS, Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) (Grant Number JP17am0101091) from AMED, Takeda Science Foundation, Uehara Memorial Foundation, and the Tokyo Biochemical Research Foundation. M.S. and R.Y. thank JSPS for Research Fellowships for Young Scientists. We thank Prof. Go Hirai{\textquoteright}s group (Kyushu University) for the use of a polarimeter. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = sep,
day = "7",
doi = "10.1021/acs.orglett.8b02306",
language = "English",
volume = "20",
pages = "5393--5397",
journal = "Organic letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "17",
}