TY - JOUR
T1 - Catalytic chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester
T2 - Hydroxy group over amino group and conjugate addition over transesterification
AU - Li, Zhao
AU - Tamura, Masamichi
AU - Yazaki, Ryo
AU - Ohshima, Takashi
N1 - Publisher Copyright:
© 2017 The Pharmaceutical Society of Japan.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - A highly chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester using a soft Lewis acid/hard Brønsted base cooperative catalyst was developed. This catalysis achieved chemoselective addition of a hydroxy group over an amino group. Moreover, soft metal alkoxide generation enabled chemoselective soft conjugate addition over hard transesterification. Various amino alcohols, including unprecedented cyclic β-amino alcohol, were applicable to the present catalysis.
AB - A highly chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester using a soft Lewis acid/hard Brønsted base cooperative catalyst was developed. This catalysis achieved chemoselective addition of a hydroxy group over an amino group. Moreover, soft metal alkoxide generation enabled chemoselective soft conjugate addition over hard transesterification. Various amino alcohols, including unprecedented cyclic β-amino alcohol, were applicable to the present catalysis.
UR - http://www.scopus.com/inward/record.url?scp=85007551434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007551434&partnerID=8YFLogxK
U2 - 10.1248/cpb.c16-00333
DO - 10.1248/cpb.c16-00333
M3 - Article
C2 - 28049909
AN - SCOPUS:85007551434
SN - 0009-2363
VL - 65
SP - 19
EP - 21
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 1
ER -