Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex

Ryoichi Kuwano; Daisuke Karube; Yoshihiko Ito

doi:10.1016/S0040-4039(99)01719-0

Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex

Ryoichi Kuwano, Daisuke Karube, Yoshihiko Ito

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A rhodium complex coordinated with a trans-chelating chiral diphosphine (S,S)-(R,R)-PhTRAP was an effective catalyst for asymmetric hydrogenation of N-acyl-1-aza-2-cycloalkene-2-carboxylates, which gave the corresponding protected cyclic α-amino acids with 73-97% ee.

Original language	English
Pages (from-to)	9045-9049
Number of pages	5
Journal	Tetrahedron Letters
Volume	40
Issue number	51
DOIs	https://doi.org/10.1016/S0040-4039(99)01719-0
Publication status	Published - Dec 17 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(99)01719-0

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title = "Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex",

abstract = "A rhodium complex coordinated with a trans-chelating chiral diphosphine (S,S)-(R,R)-PhTRAP was an effective catalyst for asymmetric hydrogenation of N-acyl-1-aza-2-cycloalkene-2-carboxylates, which gave the corresponding protected cyclic α-amino acids with 73-97% ee.",

author = "Ryoichi Kuwano and Daisuke Karube and Yoshihiko Ito",

year = "1999",

month = dec,

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doi = "10.1016/S0040-4039(99)01719-0",

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journal = "Tetrahedron Letters",

issn = "0040-4039",

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T1 - Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex

AU - Kuwano, Ryoichi

AU - Karube, Daisuke

AU - Ito, Yoshihiko

PY - 1999/12/17

Y1 - 1999/12/17

N2 - A rhodium complex coordinated with a trans-chelating chiral diphosphine (S,S)-(R,R)-PhTRAP was an effective catalyst for asymmetric hydrogenation of N-acyl-1-aza-2-cycloalkene-2-carboxylates, which gave the corresponding protected cyclic α-amino acids with 73-97% ee.

AB - A rhodium complex coordinated with a trans-chelating chiral diphosphine (S,S)-(R,R)-PhTRAP was an effective catalyst for asymmetric hydrogenation of N-acyl-1-aza-2-cycloalkene-2-carboxylates, which gave the corresponding protected cyclic α-amino acids with 73-97% ee.

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U2 - 10.1016/S0040-4039(99)01719-0

DO - 10.1016/S0040-4039(99)01719-0

M3 - Article

AN - SCOPUS:0033579582

SN - 0040-4039

VL - 40

SP - 9045

EP - 9049

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 51

ER -

Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex

Abstract

All Science Journal Classification (ASJC) codes

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