@article{57d03f26c43a4165919caeb5855432bc,
title = "Catalytic Aerobic Cross-Dehydrogenative Coupling of Azlactones en Route to α,α-Disubstituted α-Amino Acids",
abstract = "We developed a catalytic aerobic method to synthesize α,α-disubstituted α-amino acids through cross-dehydrogenative coupling of azlactones. Combining an iron catalyst with a bisoxazolidine ligand resulted in high catalytic performance, and cross-coupling with an indole proceeded smoothly under aerobic conditions. A wide variety of α-aryl and aliphatic amino acid derived azlactones were applied to the present catalysis. In addition, a quaternary carbon could be constructed using oxindole and benzofuranone under aerobic conditions. ",
author = "Taro Tsuji and Takafumi Tanaka and Tsukushi Tanaka and Ryo Yazaki and Takashi Ohshima",
note = "Funding Information: This work was financially supported by JSPS KAKENHI Grant No. JP15H05846 in Middle Molecular Strategy, No. JP18H04263 in Precisely Designed Catalysts with Customized Scaffolding, Grant-in-Aid for Scientific Research (B) (No. JP17H03972), Grant-in-Aid for Challenging Research (Exploratory) (No. JP19K22501), and Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant No. JP19am0101091. T.T. thanks JSPS for a predoctoral fellowship. R.Y. thanks Takeda Science Foundation for financial support. Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",
year = "2020",
month = jun,
day = "5",
doi = "10.1021/acs.orglett.0c01248",
language = "English",
volume = "22",
pages = "4164--4170",
journal = "Organic letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "11",
}