TY - JOUR
T1 - Ca2+-mediated suppression of the GABA-response through modulation of chloride channel gating in frog sensory neurones
AU - Behrends, Jan C.
AU - Maruyama, Tohru
AU - Tokutomi, Naofumi
AU - Akaike, Norio
N1 - Funding Information:
We thankD rs. G. ten BruggencatLe.,J . Larson-PriorH, .D. Lux and R.D. Sheridan for readingt he manuscriptT. his researchw as supportedb y Grants-in-Aid 611070056,1 30403i and 6148109f romthe JapaneseM inistryo f EducationS, cience and Culture( N.A.).
PY - 1988/4/12
Y1 - 1988/4/12
N2 - A suppressant effect of intracelullar free Ca2+ on the γ-aminobutyric acid (GABA)-induced chloride inward current (ICl(GABA)) was studied in isolated frog sensory neurones under whole cell voltage clamp. Voltage-dependent Ca2+ influx elicited during the steady state of ICl(GABA)-induced a fast, slowly recovering current relaxation in the outward direction, the amplitude of which was dependent on total Ca2+ influx. This suppressant effect showed specificity for different divalent actions, suggesting action at a specific intracellular effector. Single channel recording revealed a Ca2+-dependent decrease in the duration of the open time of the GABA-gated Cl- channel without change in single channel conductance.
AB - A suppressant effect of intracelullar free Ca2+ on the γ-aminobutyric acid (GABA)-induced chloride inward current (ICl(GABA)) was studied in isolated frog sensory neurones under whole cell voltage clamp. Voltage-dependent Ca2+ influx elicited during the steady state of ICl(GABA)-induced a fast, slowly recovering current relaxation in the outward direction, the amplitude of which was dependent on total Ca2+ influx. This suppressant effect showed specificity for different divalent actions, suggesting action at a specific intracellular effector. Single channel recording revealed a Ca2+-dependent decrease in the duration of the open time of the GABA-gated Cl- channel without change in single channel conductance.
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U2 - 10.1016/0304-3940(88)90502-2
DO - 10.1016/0304-3940(88)90502-2
M3 - Article
C2 - 2454421
AN - SCOPUS:0023819732
SN - 0304-3940
VL - 86
SP - 311
EP - 316
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -