Cardiovascular and metabolic diseases comorbid with psoriasis: Beyond the skin

Masutaka Furue, Gaku Tsuji, Takahito Chiba, Takafumi Kadono

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)


A close association of systemic inflammation with cardiovascular diseases and metabolic syndrome is recently a popular topic in medicine. Psoriasis is a chronic inflammatory skin disease with a prevalence of approximately 0.1-0.5% in Asians. It is characterized by widespread scaly erythematous macules that cause significant physical and psychological burdens for the affected individuals. The accelerated inflammation driven by the TNF-α/IL-23/IL-17A axis is now known to be the major mechanism in the development of psoriasis. Psoriasis is not a mere skin disease; it is significantly associated with cardiovascular diseases and metabolic syndrome, which suggests that the chronic skin inflammation extends the systemic inflammation beyond the skin. In this article, we review the epidemiological and pathological aspects of psoriasis and its comorbidities.

Original languageEnglish
Pages (from-to)1613-1619
Number of pages7
JournalInternal Medicine
Issue number13
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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