TY - JOUR
T1 - Cardiac magnetic resonance performs better in the detection of functionally significant coronary artery Stenosis compared to single-photon emission computed Tomography and Dobutamine stress echocardiography
AU - Kamiya, Kiwamu
AU - Sakakibara, Mamoru
AU - Asakawa, Naoya
AU - Yamada, Shiro
AU - Yoshitani, Takashi
AU - Iwano, Hiroyuki
AU - Komatsu, Hiroshi
AU - Naya, Masanao
AU - Chiba, Satoru
AU - Yamada, Satoshi
AU - Manabe, Osamu
AU - Kikuchi, Yasuka
AU - Oyama-Manabe, Noriko
AU - Oba, Koji
AU - Tsutsui, Hiroyuki
N1 - Publisher Copyright:
© Japanese Circulation Society. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Background: Fractional flow reserve (FFR) measured on catheterization is now widely used for the diagnosis of functional myocardial ischemia in patients with coronary artery disease (CAD). FFR, however, is invasive and carries potential procedural complications. Therefore, the aim of this study was to compare the diagnostic capability in functionally significant stenosis identified on FFR, between cardiac magnetic resonance myocardial perfusion imaging (CMR-MPI), single-photon emission computed tomography MPI (SPECT-MPI), and dobutamine stress echocardiography (DSE) in patients with CAD.Methods and Results: A total of 25 patients who had at least 1 angiographic stenosis ≥50% on coronary angiography was studied. CMR-MPI, SPECT-MPI and DSE were done before FFR measurement. FFR was measured in all 3 major epicardial coronary arteries. Out of 71 vascular territories excluding 4 territories due to inadequate imaging, 29 (41%) had FFR <0.80. The sensitivity of CMR-MPI was significantly higher than that of SPECT-MPI and DSE (P=0.02 and P=0.001, respectively). The area under the receiver operating characteristic curve (AUC) for CMR-MPI (AUC, 0.92) was significantly greater than for SPECT-MPI (AUC, 0.73; P=0.006) and DSE (AUC, 0.69; P<0.001).Conclusions: CMR-MPI performed well in the detection of functionally significant stenosis defined according to FFR, and had the highest diagnostic sensitivity among the 3 modalities tested in patients with CAD.
AB - Background: Fractional flow reserve (FFR) measured on catheterization is now widely used for the diagnosis of functional myocardial ischemia in patients with coronary artery disease (CAD). FFR, however, is invasive and carries potential procedural complications. Therefore, the aim of this study was to compare the diagnostic capability in functionally significant stenosis identified on FFR, between cardiac magnetic resonance myocardial perfusion imaging (CMR-MPI), single-photon emission computed tomography MPI (SPECT-MPI), and dobutamine stress echocardiography (DSE) in patients with CAD.Methods and Results: A total of 25 patients who had at least 1 angiographic stenosis ≥50% on coronary angiography was studied. CMR-MPI, SPECT-MPI and DSE were done before FFR measurement. FFR was measured in all 3 major epicardial coronary arteries. Out of 71 vascular territories excluding 4 territories due to inadequate imaging, 29 (41%) had FFR <0.80. The sensitivity of CMR-MPI was significantly higher than that of SPECT-MPI and DSE (P=0.02 and P=0.001, respectively). The area under the receiver operating characteristic curve (AUC) for CMR-MPI (AUC, 0.92) was significantly greater than for SPECT-MPI (AUC, 0.73; P=0.006) and DSE (AUC, 0.69; P<0.001).Conclusions: CMR-MPI performed well in the detection of functionally significant stenosis defined according to FFR, and had the highest diagnostic sensitivity among the 3 modalities tested in patients with CAD.
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U2 - 10.1253/circj.CJ-13-1454
DO - 10.1253/circj.CJ-13-1454
M3 - Article
C2 - 25109426
AN - SCOPUS:84908237690
SN - 1346-9843
VL - 78
SP - 2468
EP - 2476
JO - Circulation Journal
JF - Circulation Journal
IS - 10
ER -