Carcinogenesis and histogenesis of esophageal carcinoma

Keizo Sugimachi, Kohei Sumiyoshi, Tadahiro Nozoe, Mitsuhiro Yasuda, Masayuki Watanabe, Kaoru Kitamura, Shin‐Ichi ‐I Tsutsui, Masaki Mori, Hiroyuki Kuwano

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Dysplasia is one of the most important subjects regarding carcinogenesis of the esophagus, because there is continuing controversy as to whether esophageal dysplasia is a cancerous lesion or a noncancerous lesion. In this study, it is histopathologically shown that dysplasia has a close correlation with cancer itself and that there is no substantial difference in the cell proliferative activity of dysplasia and intraepithelial carcinoma. These findings thus show that dysplasia has as high a potential for malignancy, thus it should be treated as an extremely early cancerous lesion of the esophagus to substantially improve the long term results of this disease. Conversely, esophageal carcinoma with glandular and/or mucus‐secreting components is commonly found in addition to the ordinary component of squamous cell carcinoma, which indicates that this type of esophageal tumor originates not only from the squamous epithelium but also from the esophageal mucus gland or the ductal epithelium. These findings support the concept of field carcinogenesis in esophageal carcinoma. Cancer 1995;75:1440‐5.

Original languageEnglish
Pages (from-to)1440-1445
Number of pages6
Issue number6 S
Publication statusPublished - Mar 15 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


Dive into the research topics of 'Carcinogenesis and histogenesis of esophageal carcinoma'. Together they form a unique fingerprint.

Cite this