Capturing the mammalian hippo: Elucidating its role in cancer

Miki Nishio, Kohei Otsubo, Tomohiko Maehama, Koshi Mimori, Akira Suzuki

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)


The Hippo pathway is an evolutionarily conserved kinase cascade involved in cell growth, apoptosis, development and migration. It is also crucial for stem cell self-renewal and the maintenance of genomic stability. In addition, this pathway has the unique capacities to sense aspects of tissue architecture, such as cell polarity and mechanical tensions imposed by the surrounding microenvironment, and to control organ size and shape. All of these properties are frequently altered in tumor cells. In this review, we summarize how dysregulation of mammalian Hippo signaling is implicated in cancer.

Original languageEnglish
Pages (from-to)1271-1277
Number of pages7
JournalCancer Science
Issue number10
Publication statusPublished - Oct 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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