Capturing the mammalian hippo: Elucidating its role in cancer

Miki Nishio; Kohei Otsubo; Tomohiko Maehama; Koshi Mimori; Akira Suzuki

doi:10.1111/cas.12227

Capturing the mammalian hippo: Elucidating its role in cancer

Miki Nishio, Kohei Otsubo, Tomohiko Maehama, Koshi Mimori, Akira Suzuki

Research output: Contribution to journal › Review article › peer-review

38 Citations (Scopus)

Abstract

The Hippo pathway is an evolutionarily conserved kinase cascade involved in cell growth, apoptosis, development and migration. It is also crucial for stem cell self-renewal and the maintenance of genomic stability. In addition, this pathway has the unique capacities to sense aspects of tissue architecture, such as cell polarity and mechanical tensions imposed by the surrounding microenvironment, and to control organ size and shape. All of these properties are frequently altered in tumor cells. In this review, we summarize how dysregulation of mammalian Hippo signaling is implicated in cancer.

Original language	English
Pages (from-to)	1271-1277
Number of pages	7
Journal	Cancer Science
Volume	104
Issue number	10
DOIs	https://doi.org/10.1111/cas.12227
Publication status	Published - Oct 2013

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/cas.12227

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AU - Mimori, Koshi

AU - Suzuki, Akira

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AB - The Hippo pathway is an evolutionarily conserved kinase cascade involved in cell growth, apoptosis, development and migration. It is also crucial for stem cell self-renewal and the maintenance of genomic stability. In addition, this pathway has the unique capacities to sense aspects of tissue architecture, such as cell polarity and mechanical tensions imposed by the surrounding microenvironment, and to control organ size and shape. All of these properties are frequently altered in tumor cells. In this review, we summarize how dysregulation of mammalian Hippo signaling is implicated in cancer.

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Capturing the mammalian hippo: Elucidating its role in cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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