Cancer stem cells of the digestive system

Hugh S. Colvin; Naohiro Nishida; Jun Koseki; Masamitsu Konno; Koichi Kawamoto; Kenta Tsunekuni; Yuichiro Doki; Masaki Mori; Hideshi Ishii

doi:10.1093/jjco/hyu146

Cancer stem cells of the digestive system

Hugh S. Colvin, Naohiro Nishida, Jun Koseki, Masamitsu Konno, Koichi Kawamoto, Kenta Tsunekuni, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Stem cells of the digestive system are ideal in many ways for research, given they are abundant, highly proliferative and have a uniform structural arrangement. This in turn has enormously aided the research of cancer stem cells of the digestive system, which is now shaping our understanding of cancer stem cells. In this review, the recent advances in the understanding of cancer stem cells of the digestive system have been summarized, including aspects such as their identification, origin, cell-cycle dormancy, relationship with epithelial-mesenchymal transition, cellular metabolism and the underlying molecular mechanisms. Newly acquired knowledge concerning cancer stem cells have led to the development of novel cancer therapeutics with provisional yet encouraging results.

Original language	English
Pages (from-to)	1141-1149
Number of pages	9
Journal	Japanese journal of clinical oncology
Volume	44
Issue number	12
DOIs	https://doi.org/10.1093/jjco/hyu146
Publication status	Published - Dec 1 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jjco/hyu146

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AU - Colvin, Hugh S.

AU - Nishida, Naohiro

AU - Koseki, Jun

AU - Konno, Masamitsu

AU - Kawamoto, Koichi

AU - Tsunekuni, Kenta

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Ishii, Hideshi

PY - 2014/12/1

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AB - Stem cells of the digestive system are ideal in many ways for research, given they are abundant, highly proliferative and have a uniform structural arrangement. This in turn has enormously aided the research of cancer stem cells of the digestive system, which is now shaping our understanding of cancer stem cells. In this review, the recent advances in the understanding of cancer stem cells of the digestive system have been summarized, including aspects such as their identification, origin, cell-cycle dormancy, relationship with epithelial-mesenchymal transition, cellular metabolism and the underlying molecular mechanisms. Newly acquired knowledge concerning cancer stem cells have led to the development of novel cancer therapeutics with provisional yet encouraging results.

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Cancer stem cells of the digestive system

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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